摘要
目的:评价血清血清淀粉样蛋白A(SAA)、血清干扰素G诱导蛋白10(IP-10)及降钙素原(PCT)在慢性阻塞性肺疾病急性加重期(AECOPD)患者中的诊断价值。方法:(1)选取AECOPD患者60例,s COPD患者52例,对照组28例,构成随机平行资料。(2)另随机选择其中19例AECOPD患者及其稳定期构成COPD急性加重-稳定期配对资料。采用酶联免疫法测定各组患者血清标记物水平,比较并分析其异同。结果:(1)AECOPD组SAA浓度与s COPD组SAA浓度差异有统计学意义(P<0.05)。(2)AECOPD组与s COPD组血清IP-10浓度比较有统计学差异(P<0.05)。(3)AECOPD组与s COPD组血清PCT浓度比较无统计学差异(P>0.05)。结论:AECOPD组血清SAA和IP-10浓度较s COPD组升高,有助于AECOPD的诊断,其诊断敏感度及特异度分别为100.0%、54.9%,96.1%、75.0%。本研究结果中PCT不能用于鉴别AECOPD与s COPD。
Objective To assess the clinical significance of SAA,IP-10 and PCT in the diagnosis of AECOPD.Methods Sixty AECOPD patients,52 with s COPD,and 28 healthy subjects were assigned to three groups.Clinical data and serum specimen were obtained from another 19 AECOPD patients at stable stage as AECOPDs COPD group.Serum levels of SAA,IP10 and PCT were quantitatively measured by ELISA.Levels of multiple serum markers were statistically compared among different groups.Results The concentration of SAA significantly differed between the AECOPD and s COPD groups（P〈0.05）,so did the concentration of IP-10（P〈0.05）;no statistical significance was found in terms of serum PCT concentration between the two groups（P〈0.05）.Conclusions As compared with the s COPD group,levels of serum SAA and IP-10 in the AECOPD group were significantly elevated,which is helpful in the diagnosis of AECOPD with a sensitivity and specificity of 100% and54.9% for SAA,and 96.1% and 75.0% for IP-10.However,PCT level failed to identify AECOPD from s COPD.
出处
《实用医学杂志》
CAS
北大核心
2016年第8期1277-1279,共3页
The Journal of Practical Medicine
