摘要
目的探讨紫杉醇脂质体联合顺铂治疗不同肿瘤分期宫颈癌患者的近期疗效。方法选取2006年3月至2014年3月间收治的64例宫颈癌患者,根据国际妇产科联盟（FIGO）的分期标准,分为ⅠB2期组（16例）、ⅡA期组（22例）和ⅡB期组（26例）,均采用紫杉醇脂质体联合顺铂治疗1~3个疗程,然后行宫颈癌根治术治疗,观察各分期患者病灶大小的变化及化疗的不良反应。结果3组患者化疗后肿瘤大小均较化疗前明显缩小,差异有统计学意义（P〈0.05）;且随着恶性程度进展,化疗对肿瘤大小的影响也越明显,组间差异有统计学意义（P〈0.05）。ⅠB2期组、ⅡA期组和ⅡB期组患者总有效率分别为75.0%（12/16）、77.3%（17/22）和88.5%（23/26）,ⅡB期组疗效显著优于ⅠB2期组和ⅡA期组,差异有统计学意义（P〈0.05）,但ⅠB2期、ⅡA期组间差异无统计学意义（P〉0.05）。3组患者的不良反应差异无统计学意义（P〉0.05）。结论紫杉醇脂质体联合顺铂治疗宫颈癌疗效良好,且随着肿瘤恶化程度的上升化疗效果会更加显著,安全性较好,能够为手术创造良好条件,值得在临床上推广和应用。
Objective To explore the evaluation of the short-term efficacy of paclitaxel liposome combined with cisplatin in cervical cancer patients with different tumor staging. Methods From March2006 to March 2014 in Wuhan Commercial Staff Hospital,64 cases of patients with cervical cancer were selected. According to the International Union of Gynecology and Obstetrics（ FIGO） staging standard,the patients were divided into ⅠB2 stage（ n = 16）,ⅡA stage（ n = 22） and ⅡB stage（ n = 26） groups. All aptietns were adopt paclitaxel liposome combined cisplatin chemotherapy in the treatment of 1 ~ 3 period,and received cervical cancer radical treatment. The change of lesion size and adverse reaction of chemotherapy of patients were observed. Results The tumor size of the three groups were significantly decreased compared with that before chemotherapy,and the difference was statistically significant（ P〈0. 05）. With the progression of malignancy,the effect of chemotherapy on tumor size was more obvious,and the difference was statistically significant（ P〈0. 05）. The total effective rate was 75. 0%（ 12/16）,77. 3%（ 17/22） and88. 5%（ 23/26） in ⅠB2 stage group,ⅡA stage group and ⅡB stage group. The effect of ⅡB stage group was significantly better than that of ⅠB2 stage group and ⅡA stage group,and the difference was statistically significant（ P〈0. 05）. However,there was no significant difference between ⅠB2 stage group andⅡA stage group（ P〈0. 05）. There was no significant difference in the adverse reactions of the three groups（ P〈0. 05）. Conclusions Neoadjuvant chemotherapy with paclitaxel liposome combined with cisplatin in the treatment of cervical cancer can achieve good effect. With the increase of the degree of tumor progression,the effect of chemotherapy is more obvious,and the safety is good,and it can create good conditions for the operation,and is worth to be popularized and applied in clinic.
出处
《中国肿瘤临床与康复》
2016年第5期539-542,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
子宫肿瘤
肿瘤分期
药物疗法
治疗结果
Cervical neoplasms
Tumor stage
Drug therapy
Treatment outcome
