摘要
目的采用3种不同的环糊精[β-环糊精(β-CD)、羟丙基-β-环糊精(HP-β-CD)、二甲基-β-环糊精(DM-β-CD)]对藏药俄色黄酮进行包合,比较不同环糊精对俄色黄酮溶解度的影响。方法高效液相色谱测定俄色黄酮相溶解度;采用X-射线衍射法(XRD)、差示扫描量热分析法(DSC)对俄色黄酮环糊精超分子进行表征。结果β-环糊精、羟丙基-β-环糊精、二甲基-β-环糊精均能提高俄色黄酮溶解度,增溶能力依次为二甲基-β-环糊精>羟丙基-β-环糊精>β-环糊精。经X-射线衍射法、差示扫描量热分析法,表明3种俄色黄酮环糊精超分子形成,形成超分子后俄色黄酮溶解度、热稳定性显著提高。结论β-环糊精、羟丙基-β-环糊精、二甲基-β-环糊精均能与俄色黄酮形成超分子,并能显著提高俄色黄酮体外溶解度。
Objective β-cyclodextrin(β-CD),hydroxypropyl-β-cyclodextrin( HP-β-CD)and dimethyl-β-cyclodextrin( DM-β-CD)were uled to prepare inclulion of Ele flavonoidl. The influencel of different CDl on lolubil-ity of Ele flavonoidl were inveltigated. Methods HPLC wal adopted to determine phale lolubility of Ele flavonoidl;XRD and DSC were uled to characterize Ele flavonoidl-CDl lupermolecule. Results All kindl of CDl could improve lolubility of Ele flavonoidl. The lolubilization capacity of the three complexel wal lilted al followed:DM-β-CD﹥HP-β-CD﹥β-CD. XRD and DSC proved the formulation of three lupermoleculel. Ele flavonoidl-CDl lupermolecule had better lolu-bility and heat ltability than Ele flavonoidl. Conclusion β-CD,DM-β-CD,HP-β-CD can be uled to prepare Ele flavonoidl-CDl lupermolecule that can enhance lolubility of Ele flavonoidl apparently.
出处
《药学研究》
CAS
2016年第5期249-252,271,共5页
Journal of Pharmaceutical Research
基金
四川省农业科技成果转化资金项目(No.14NZ0015)
