摘要
消化性溃疡是胃和十二指肠的慢性炎症疾病。现已证明,幽门螺杆菌感染是导致溃疡的重要因素,其次是长期服用非甾体抗炎药。此外,胃酸-胃蛋白酶的分泌及宿主消化道的防御特性等在溃疡的发病中也起着重要作用。治疗消化性溃疡的药物主要有:(1)抗酸药物,包括钙、铝、镁剂及复方制剂等;(2)抑制酸分泌的药物,包括 H2受体拮抗剂、毒蕈碱受体拮抗剂和质子泵抑制剂;(3)粘膜保护剂(在溃疡面形成保护膜的药物);(4)前列腺素类似物等。将上述药物有选择的与抗生素联合使用,可治愈幽门螺杆菌感染,从而加速溃疡的愈合,提高常规治疗无效的消化性溃疡的治愈率,使消化性溃疡的年复发率由50%降到0%～2%。
Peptic ulcer disease is a type of chronic gastric and duodenal inflammatory lesion.Infection with Helicobacter pylori is causally related to the majority of cases of both duodenal and gastric ulcer.The second most common cause of peptic ulcers is induced by administing nonsteroidal anti-inflammatory drugs.Gastric acid and pepsin as well as the host factors may also play important roles in the pathogenesis of the disease. The drugs used for treatment of peptic ulcer include antacids,inhibitors of gastric acid secretion(H2-recep- tor antagonists,muscarine receptor antagonists,proton pump inhibitors),the protective agents for mucosa, and prostaglandins.Helicobacter pylori eradication may contribute to the reduction in time needed for ulcer healing.Moreover,eradication of Helicobacter pylori infection may enhance healing of ulcers refractory to conventional therapy and substantially reduce the risk of ulcer recurrence(from 50 percent to 0 to 2 percent in 1 year).
出处
《当代医学》
1997年第1期41-50,共10页
Contemporary Medicine
关键词
消化性溃疡
药物治疗
幽门螺杆菌
根除疗法
Peptic ulcer
Pharmaceutical drugs
Helicobacter pylori
Eradication therapy
