摘要
目的:探讨三七总皂苷对大鼠脊髓损伤(SCI)后运动功能恢复的作用。方法:正常SD大鼠随机分为5组(n=8):正常对照组(Normal)、假手术组(Sham)、脊髓损伤(SCI)和脊髓损伤+三七总皂苷组(PNS)(n=8)。所有大鼠分别在造模前及造模后第1、3、7、14、21和28天接受运动功能评分(BBB)和运动诱发电位(MEP)检查,观察大鼠后肢运动功能的恢复情况。结果:造模后,Sham组、PNS组、SCI组BBB评分低于正常;MEP波幅低于正常;潜伏期较正常延长。PNS组与同期SCI组比较,第7、14、21、28天的BBB评分差异有统计学意义(P<0.05);第7天、14天、21天、28天,MEP检查波幅(Amp)和潜伏期(Lat)组内有显著差异,并且与同期SCI组比较差异有统计学意义(P<0.05)。结论:三七总皂苷可促进大鼠SCI后运动功能的恢复。
Objective： To investigate the effect of Panax NotoginSeng Saponins（PNS） on functional recovery of rats with spinal cord injury （SCI） after exercise. Methods： SD normal rats were randomly divided into normal control group （Normal） and control group （Sham）, spinal cord injury （SCI） and spinal cord injury （SCI） ＋ panax notoginseng saponins group （PNS） （ n = 8）. All rats were given basso beattie bresnahan motor function score （BBB） and motor evoked potentials （MEP） examination to observe rat hind limb motor function recovery before operation and 1,3,7,14,21,28 days after operation. Results： After operation, the BBB scrapes of Sham group, PNS group, SCI group were lower than that of normal; MEP amplitude was lower than that of normal group; the incubation time was prolonged compared with that in normal group. In PNS group compared with that in the SCI group, BBB scores at 7,14,21 and 28 days was significantly different（ P 〈 0.05）. There were significant differences in the latency （Lat） and amplitude（Amp） of MEP within PNA subgroups or between the PNS and the SCI groups at 7, 14,21,28 days（ P 〈 0.05）. Conclusion： PNS can promote the recovery of motor function after SCI in rats.
出处
《中国应用生理学杂志》
CAS
CSCD
2016年第2期142-145,共4页
Chinese Journal of Applied Physiology
关键词
脊髓损伤
三七总皂苷
运动诱发电位
大鼠
spinal cord injury
panax notoginseng saponins（Traditional Chinese Medicine）
motor evoked potentials
rats
