摘要
目的评价厚朴排气合剂治疗手术所致胃肠动力障碍的效果及安全性。方法检索Pub Med、EMBASE、Cochrane Library、Web of Knowledge、中国科学引文数据库、中国知网、维普数据库及万方数据库,检索时间为各数据库建库至2015年3月。纳入应用厚朴排气合剂治疗各类手术后胃肠动力障碍的随机对照试验。由2名研究者独立筛选文献并提取数据及进行文献质量评价,采用Stata 12软件和Rev Man 5.3软件对主要结局指标术后肛门首次排气时间及次要结局指标术后首次排便时间、肠鸣音恢复时间进行Meta分析。结果共纳入符合标准的文献16篇,总样本量为2247例。仅有4篇文献报道了具体的随机分配方法。Meta分析结果显示,厚朴排气合剂对腹部非胃肠吻合术、妇科手术、剖宫产术等各类术后胃肠动力障碍均具有明确的疗效,能显著缩短术后首次排气时间(WMD=-11.82,95%CI:-14.80^-8.84,P<0.01;WMD=-18.19,95%CI:-27.58^-8.79,P<0.01;WMD=-10.95,95%CI:-16.22^-5.69,P<0.01)、排便时间(WMD=-8.58,95%CI:-15.95^-1.21,P=0.02;WMD=-28.4,95%CI:-35.4^-20.68,P<0.01;WMD=-15.74,95%CI:-30.29^-1.20,P=0.03)及肠鸣音恢复时间(WMD=-3.52,95%CI:-5.08^-1.96,P<0.01;WMD=-8.68,95%CI:-10.37^-6.99,P<0.01;WMD=-9.58,95%CI:-14.16^-5.01,P<0.01),未见明显的药物不良反应。结论厚朴排气合剂用于术后胃肠动力障碍的治疗效果明确,短期使用未发现明显的药物不良反应。
Objective To evaluate the effect and safety of Houpo Paiqi Mixture （ 厚朴排气合剂） treating postoperative gastrointestinal motility disorders. Methods Reviewed all published literature from PubMed, EMBASE, Cochrane Library, Web of Knowledge, Chinese Science Citation Database, China National Knowledge Infrastructure, VIP Data and WanFang Data, from the establishment of the databases to March of 2015. The randomized controlled trials of Houpo Paiqi Mixture treating types of disorders of gastrointestinal motility after operation were included. Two reviewers screened the papers, extracted data and evaluated papers quality independently. Made Meta analysis on the primary outcome index （the first flatus time after operation） and the secondary outcome indexes （the first defecation time after operation and the recovery time of borborygmus） adopting the software of Stata 12 and RevMan 5.3. Results Sixteen papers accorded with standard were included. The total sample size was 2247 cases. Only 4 papers recorded concrete random allocation methods. Meta analysis results showed that Houpo Paiqi Mixture was effective on disorders of gastrointestinal motility after operations, such as abdominal non gastrointestinal anastomosis, gynecologic operations, cesarean sections. It could shorten the first flatus time after operation （ WMD = - 11.82, 95% CI. -14.80- -8.84, P〈0.01; WMD= -18.19,95%CI： -27.58- -8.79, P〈0.01; WMD= -10.95, 95% CI： -16.22- -5.69, P〈0.01）, the first defecation time （WMD= -8.58, 95%CI： -15.95- -1.21, P= 0.02; WMD= -28.4,95%CI： -35.4- -20.68, P〈0.01; WMD= -15.74, 95%CI： -30.29- -1.20, P = 0. 03 ） and the recovery time of borborygmus （WMD = - 3.52, 95% CI ： - 5.08 - - 1.96, P 〈 0. 01 ; WMD = -8.68, 95%CI： -10.37- -6.99, P〈0.01; WMD= -9.58, 95%CI： -14.16- -5.01, P〈0.01）. No obvious drug adverse reaction. Conclusion Houpo Paiqi Mixture was effective in treating disorders of gastrointestinal motility after operation. There was no obvious drug adverse reaction during short-term application.
出处
《中医杂志》
CSCD
北大核心
2016年第9期747-752,共6页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81573795)
甘肃省中医药管理局中医药科研项目(GZK-2012-51)
甘肃省中医方药挖掘与创新转化重点实验室/甘肃省中药新产品创制省级工程实验室开放基金(ZYEYZH-KJ-2015-006)
关键词
厚朴排气合剂
术后胃肠动力障碍
META分析
Houpo Paiqi Mixture
post-operative gastrointestinal motility disorders
Meta analysis
