摘要
目的:观察血栓通联合长春西汀注射液治疗后循环缺血综合征的疗效及其对血液流变学的影响。方法:将符合纳入标准的94例后循环缺血综合征患者随机分为治疗组和对照组,每组47例,对照组予以西医常规治疗,治疗组在对照组基础上联合血栓通注射液治疗,连续治疗14 d,观察两组临床疗效、血液流变学改善情况(全血高切黏度、低切黏度、血浆比黏度、纤维蛋白原含量)及颅脑TCD相关指标(平均血流速度、搏动指数、阻力指数)的变化。结果:治疗组临床总有效率为93.6%,高于对照组的74.5%,差异有统计学意义(P<0.05);两组患者血液流变学相关指标数值较治疗前均有所下降,而治疗组下降更明显,且两组的PI、RI均较治疗前减小,MV均较治疗前增加,但治疗组PI、RI减小及MV增加较明显,差异均有统计学意义(P<0.05)。结论:血栓通联合长春西汀治疗后循环综合征有较好的疗效。
Objective： To investigate the clinical efficacy of Xueshuantong and Vinpocetine on posterior circulation ischemia syndrome, as well as the influence on hemorheology. Methods： The 94 patients with posterior circulation ischemia syndrome meeting the inclusion criteria were randomly divided into treatment and control groups, with 47 cases in each. Patients were treated by conventional western medicine treatment in control group; and patients in treatment group were treated with Xueshuantong injection based on the same treatment as the control group, with continuous treatment for 14 days. The clinical efficacy, hemorheology situation （whole blood viscosity, low shear viscosity, plasma than changes in viscosity and fibrinogen content） and brain TCD index （average flow velocity, pulsatility index （PI） and the resistance index） were observed. Results： The clinical total effective rate was 93.6% in treatment group and 74.5% in control group, and the treatment group showed higher rate than the control group, with statistical difference （P〈0.05）. The hemorheology index was reduced in two groups, and the treatment group decreased more significantly; The PI and RI were reduced and MV was increased in two groups, and the treatment group showed lower PI and RI as well as higher MV than the control group; there was statistically significant difference （P〈0.05）. Conclusion： The application of Xueshuantong and Vinpocetine showed good clinical efficacy on posterior circulation ischemia syndrome.
出处
《中医药导报》
2016年第9期80-82,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
