摘要
目的:系统评价头针疗法治疗血管性痴呆(Vascular dementia,VD)的临床效果以及安全性。方法:计算机检索Cochrane Library、Pubmed、Embase、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、中国科技期刊全文数据库(VIP)和万方数据库等,检索时间限定为建库至2015年6月,检索所有纳入比较头针疗法治疗血管性痴呆的随机对照试验(Randomized Controll Trials,RCTs),并追索纳入研究的参考文献。由两位评价者独立对纳入研究的质量进行严格评价和资料提取后,采用Rev Man 5.2软件进行Meta分析。结果:共纳入6个随机对照试验,共631例患者。Meta分析结果显示:对于血管性痴呆患者,试验组和对照组相比在提高MMSE的评分方面无显著差异,合并治疗效应为1.48[-0.21,3.17](P=0.09),不具有统计学意义;而对于降低ADL评分与及提高HDS评分,试验组与对照组两者能力相当,合并效应分别为-0.25[-3.32,2.83](P=0.88)、0.35[-1.01,1.70](P=0.62),均无统计学意义。头针疗法与对照组比较,合并OR值为1.66,95%可信区间CI为[1.06,2.62],整体效果检验Z=2.21,P=0.03,具有统计学意义,表明头针疗法对血管性痴呆的治疗效果优于对照组。结论:基于纳入6篇文献的Meta分析结果,头针疗法能有效治疗血管性痴呆;但由于有待于纳入文献质量的提高、样本量扩大以及试验方法条件改善,其疗效仍需进一步验证。
Objective：Scalp therapy evaluation of the efficacy of vascular dementia. Methods：We searched Pub Med,the Cohrane library,CNKI,Wan Fang Data,VIP database and other databases,scalp therapy included comparison of vascular dementia randomized controlled trials of methodological quality of included studies was evaluated and applied Rev Man 5.2 software for meta-analysis. Results：A total of 6 randomized controlled trials;Meta-analysis showed that：for patients with vascular dementia,the test group significantly improved MMSE scores than the control group,combined treatment effect was 1.48[-0.21,3.17]（P=0.09）,and statistically significant;but for making ADL score lower and improving HDS score,both experimental and control groups the ability to fairly,combined effect were-0.25[-3.32,2.83]（P=0.88）and 0.35[-1.01,1.70]（P=0.62）,and there was no statistically significant. compared scalp therapy with the control group,combined OR=1.66,95% confidence interval CI for the[1.06,2.62],confidence interval CI for the Z=2.21,P=0.03,statistically significant,and showed that treatment of vascular dementia scalp treatment effect than the control group. Conclusion：Based on the literature included 6Meta-analysis,scalp therapy is effective in treating vascular dementia,however,due to the quality of the included studies need to be improved to expand the sample size,with different conditions and test methods,publication bias may exist.
出处
《辽宁中医药大学学报》
CAS
2016年第5期121-124,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金青年项目(61301294)
省级大学生创新创业训练计划项目(201510572051)
