摘要
层黏连蛋白332(laminin 332)是上皮组织基底膜的主要组成蛋白之一,具有促进上皮细胞黏附、迁移和细胞分化等功能。Laminin 332是由3个不同基因编码的α3链、β3链和γ2链形成的异源三聚体糖蛋白。上皮细胞内合成的laminin 332是以前体形式存在的,分泌到细胞外基质后α3链和γ2链经蛋白酶水解而成熟。生理状态下,laminin332的主要作用是维持上皮组织中上皮与基底膜的黏合。研究表明laminin 332在多种恶性肿瘤组织中过度表达,与肿瘤的发生、发展密切相关。综述laminin 332的结构、与恶性肿瘤的关系及其在妇科肿瘤中的研究进展。
Laminin 332 is a major component of the basement membrane in epithelial tissues and plays roles in the adhesion, migration and differentiation of epithelial cells. Laminin 332 consists of three different gene products, α3, β3 and γ2chains, resulting in a heterotrimeric glycoprotein. Laminin 332 is synthesized by epithelial cells as a precursor. After secretion into the extracellular matrix, the α3 and γ2 chains undergo specific proteolytic processing to produce a mature form. Under the physiological condition, the key function of laminin 332 is sustaining the stable adhesion of epithelial cells to the underlying basement membrane in epithelial tissues. Laminin 332 has been shown to be highly expressed in various types of human malignant tumors and correlate well with tumor occurrence and development. The article is intended to review the structure of laminin 332, its relationship with malignant tumors and research progresses with gynecological tumors.
出处
《国际妇产科学杂志》
CAS
2016年第2期125-127,155,共4页
Journal of International Obstetrics and Gynecology
