摘要
目的:探讨复方黄柏液联合派瑞松治疗脂溢性皮炎的临床疗效及其对患者血清白细胞介素-8(IL-8)、白细胞介素-2(IL-2)及白细胞介素-10(IL-10)水平的影响。方法:选择于我院就诊的脂溢性皮炎患者120例,随机分为实验组和对照组,每组各60例。对照组患者采用派瑞松进行治疗,实验组患者采用复方黄柏液联合派瑞松进行治疗。比较治疗前后两组患者血清白细胞介素-2(IL-2)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)水平,并比较治疗后脂溢性皮炎复发率、复发间隔天数及临床治疗效果。结果:治疗后,与对照组相比,实验组患者血清IL-10水平及复发率明显较低(P<0.05);血清IL-2、IL-8水平及临床总有效率较高(P<0.05);痊愈至复发的间隔时间较长(P<0.05)。结论:复方黄柏液联合派瑞松能够明显提高脂溢性皮炎的临床治疗效果,降低临床复发率,可能与缓解机体的炎症反应有关。
Objective： To investigate the effect of the IL-8, IL-10 and clinical efficacy by Fufanghuangbai liquid with pevisone on the levels of serum interleukin IL-8（IL-8）, leukocyte mediated IL-2（IL-2） and leukocyte mediated IL-10（IL-10） in patients with seborrheic dermatitis and its clinical curative effects. Methods： 120 patients with seborrheic dermatitis who were treated in our hospital were selected and randomly divided into the control group and the experiment group with 60 cases in each group. The patients in the control group were treated with pevisone, while the patients in the experiment group were treated with Fufanghuangbai liquid on the basis of the control group. Then the levels of IL-2, IL-8 and IL-10 in the serum of patients, the recurrence rate, the hospitalization and the clinical effect of patients in the two groups were observed and compared before and after the treatment. Results： Compared with the control group after treatment, the levels of IL-10 in the serum of patients and the recurrence rate were lower（P〈 0.05）; the levels of IL-2and IL-8 in the serum of patients and total clinical efficiency were higher（P〈 0.05）, and the interval between the cure and the recurrence were longer（P〈 0.05）. Conclusions： The Fufanghuangbai combined with triamcinolone acetonide and econazole nitrate can significantly improve the clinical effect of the treatment of seborrheic dermatitis, reduce the rate of clinical relapse, speculated that the mechanism may be related with human T cell levels.
出处
《现代生物医学进展》
CAS
2016年第12期2284-2286,2319,共4页
Progress in Modern Biomedicine
基金
国家科技支撑计划项目(2008BAI538045)
