摘要
目的探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与颈动脉斑块和颈动脉内一中膜厚度的关系。方法选取2013年1月～2014年12月期间在瑞金医院老年科住院并具有打鼾、白天嗜睡等OSAHS症状的患者120例，对其进行多导联睡眠监测（PSG），根据呼吸暂停低通气指数（AHI）将其分为OSAHS组（80例）和非OSAHS组（40例），并将OSAHS组分为轻度组（25例）、中度组（26例）、重度组（29例），对所有入选者用彩色多普勒超声检测颈动脉内．中膜厚度（IMT）、血流阻力指数（RI）和颈动脉斑块。结果OSAHS各指标及其严重程度在合并斑块组与无斑块组未见明显差异；夜间最低血氧饱和度（minSaO2）、夜间氧饱和度低于90％的时间占总睡眠时间的百分比（TS90）均与颈动脉IMT、RI相关，且右侧颈动脉更明显；Logistic回归分析发现年龄升高是颈动脉斑块发病的独立危险因素，且年龄分层在合并斑块组与无斑块组可见显著差异。结论OSAHS所致的缺氧与颈动脉粥样硬化的形成密切相关；年龄升高是颈动脉斑块形成的独立危险因素。
Objective We investigated whether obstructive sleep apnea hypopnea syndrome （OSAHS） was associated with the carotid-artery plaque and the carotid-artery intima-media thickness （IMT）. Methods We selected 120 hospitalized patients from the Geriatric Department in Ruijin hospital during January 2013- December 2014. They had OSAHS symptoms such as snoring,daytime sleepiness and so on. All subje nea-hy- popnea index （ AHI）. Color Doppler ultrasonography was used to measure the carotid- artery intima- media thickness （IMT）, blood flow resistance index （RI）and carotid-artery plaque. Results The severity of OSAHS was not significantly associated with the carotid-artery plaque. But the nadir oxygen saturation （minSaO2）dur- ing night and the duration of an oxygen saturation below 90% ,which is expressed as a percentage of the total sleeping time（TS90） was correlated with the carotid-artery IMT and RI. Moreover, the relationship was more obvious in the right carotid artery. It was found that age was independently related to the formation of carotid- artery plaque by using the Logistic regression analysis. The age stratification was significantly associated with the carotid-artery plaque. Conclusion OSAHS-related hypoxemia is closely associated to carotid-artery ather- osclerosis. Age is an independent risk factor of carotid-artery atherosclerosis.
出处
《血栓与止血学》
2016年第1期16-20,共5页
Chinese Journal of Thrombosis and Hemostasis
