摘要
目的评价临床药师干预Ⅰ类切口手术围手术期抗菌药物预防性使用的效果。方法对某院2014年1—12月收治的1 398例Ⅰ类切口手术患者的临床资料进行回顾性分析,其中2014年1—6月收治的633例患者作为干预前组;2014年7—12月收治的765例患者作为干预后组(设置临床药师,加强对合理用药的管理与控制),比较干预前后患者围手术期预防性使用抗菌药物情况。结果干预前后两组围手术期患者抗菌药物预防性使用率分别为56.71%和28.37%,差异具有统计学意义(χ2=113.26,P<0.05)。干预前、后两组患者抗菌药物品种选择合理率分别为60.45%、89.86%,给药时机合理率分别为49.58%、82.49%,预防性应用抗菌药物疗程≤24 h者分别为11.42%、29.95%,疗程>24 h者分别为88.58%、70.05%,联合用药比率分别为10.31%、0,干预前后比较,差异均具有统计学意义(均P<0.05)。干预前后两组患者Ⅰ类切口感染发病率分别为0.79%(5/633)、0.26%(2/765),差异无统计学意义(P=0.255)。结论通过临床药师对Ⅰ类切口手术围手术期抗菌药物预防性使用干预,其使用率显著下降,使该院抗菌药物管理工作更加规范化、科学化和制度化。
Objective To evaluate effectiveness of clinical pharmacists＇ intervention in perioperative antimicrobial use in type I incisional surgery.Methods Clinical data of 1 398 patients undergoing type I incisional surgery in a hospital between January and December 2014 were analyzed retrospectively,633 patients who underwent surgery between January and June were as pre-intervention group,765 patients who underwent surgery between July and December were as post-intervention group（clinical pharmacists were assigned to strengthen the management and control of rational antimicrobial use）,antimicrobial prophylaxis between pre-intervention group and post-intervention group were compared.Results In pre-and post-intervention groups,antimicrobial prophylaxis were 56.71%and 28.37% respectively（χ2=113.26,P〈0.05）.Rational selection rates of antimicrobial types were 60.45% and89.86%respectively,rational rates of administration time were 49.58%and82.49%respectively,the rates of antimicrobial prophylaxis course≤24 hours were 11.42% and 29.95% respectively, 〉24 hours were 88.58% and 70.05% respectively,combination antimicrobial use were 10.31% and 0respectively,the differences between before and after intervention were all statistically significant（all P〈0.05）.Incidence of surgical site infection in pre-and post-intervention groups were 0.79%（5/633）and 0.26%（2/765）respectively（P=0.255）.Conclusion Through clinical pharmacists＇ intervention in perioperative antimicrobial prophylaxis in type I incisional surgery,antimicrobial prophylaxis rate decreased dramatically,antimicrobial management is more standardized,scientific and systematic.
出处
《中国感染控制杂志》
CAS
北大核心
2016年第4期269-271,276,共4页
Chinese Journal of Infection Control
关键词
临床药师
干预
围手术期
Ⅰ类切口
抗菌药物
合理用药
clinical pharmacist
intervention
perioperative period
type I incisional surgery
antimicrobial agent
rational drug use
