摘要
目的筛查厦门地区2012-2014年体检人群幽门螺杆菌（Hp）的感染水平及其潜在影响因素。方法对2012-2014年在厦门大学附属中山医院健康医学部健康体检人群进行”C尿素呼气试验检测，利用Hp感染流行病学调查问卷收集社会人口学信息、Hp知晓情况、消化道症状或疾病史、生活方式等相关数据。采用单因素和多因素logistic回归模型评估Hp感染的潜在影响因素。结果2012-2014年，分别筛查1631、1766、5257名体检人员，发现Hp感染水平稳定，感染率分别为48．9％、49．8％、50．5％，且男女Hp感染率（50．2％vs.49．8％）差异无统计学意义（P=0．702）。回收有效问卷共计1444份，Hp感染率为47．9％。在多因素logistic回归模型中，与Hp感染有统计学意义的变量包括：曾做过Hp检测（OR：0．67，95％C1：0．51-0．88，P=0．004），胃痛、胃胀（OR：2．19，95％CI：1．73-2．78，P〈0．001），饮酒（OR：1．38，95％CI：1．11-1．71，P=0．004）。Hp感染程度越严重，胃痛胃胀的比例越高，吸烟与饮酒比例也越高，但在感染严重程度最高的人群中，吸烟和饮酒率反而下降。结论厦门地区Hp感染率略低于全国自然人群感染率，但仍达50％。而Hp感染严重程度和胃痛胃胀呈正相关。有各种消化道症状人群的Hp筛查和治疗需得到重视。
Objective To investigate the prevalence of Helicobacter pylori （Hp） infection among health checkup population in Xiamen area during 2012-2014, and evaluate the potential predictors for Hp infection. Methods A cross-sectional study was conducted among health checkup population in the Zhongshan Hospital during 2012-2014. Potential participants completed 13C breath tests for helieobacter pylori infection. An epidemiological questionnaire was used to collect data on socio-demographic characteristics, the awareness of Hp-related information, the history of gastrointestinal diseases or symptoms, life styles and relevant data for each participant. Univariate and multivariate logistic regression analyses were performed to evaluate the associations of Hp infection with potential predictors. Results Three groups of individuals with 1 631, 1 766, and 5 257 persons who underwent health checkup were screened for Hp infection, and Hp prevalence was 48.9%, 49.8%, and 50.5% during 2012-2014, respectively. No significant difference in Hp prevalence was found between both sexes. A total of 1444 acceptible questionnaires were used to evaluate the associations between Hp infection and potential predictors and Hp infection was 47.9% among 1 444 eligible participants. In the multivariate logistic regression model, Hp infection was found to be associated significantly with having ever tested for Hp infection （OR, 0.67; 95%Ch 0.51-0.88; P=0.004）, the history of stomachache or gastrectasia （OR, 2.19; 95% Ch 1.73-2.78; P〈0.001）, and alcohol drinking （OR, 1.38; 95% CI： 1.11-1.71; P=0.004）. The higher the severity of Hp infection, the higher the prevalence of stomachache or gastrectasia, and smoking and alcohol drinking. However, the prevalence of smoking and alcohol drinking decreased among those with the highest severity of Hp infection. Conclusion The
出处
《中华健康管理学杂志》
CAS
2016年第2期153-158,共6页
Chinese Journal of Health Management
