摘要
本文检测６０例轮状病毒（ＨＲＶ）肠炎免疫球蛋白及Ｔ淋巴细胞亚群，并随机分为两组，治疗组除常规治疗外采用小剂量干扰素（ＩＦＮ－α）治疗，对照组常规治疗，并观察两组患儿治疗后临床疗效及免疫功能变化。结果显示急性期患儿血清ＩｇＡ、ＩｇＧ、ＩｇＭ及ＣＤ４、ＣＤ４／ＣＤ８均明显降低；ＣＤ８明显升高（Ｐ均＜０．０１）。两组治疗后，治疗组总有效率９０．０％，明显高于对照组５０．０％（Ｐ＜０．０１），且治疗组ＩｇＡ、ＩｇＧ、ＩｇＭ及ＣＤ４、ＣＤ４／ＣＤ８较治疗前明显升高，ＣＤ８明显降低（Ｐ均＜０．０１），提示ＨＲＶ肠炎存在着免疫功能紊乱，小剂量干扰素有助于患儿病程缩短，增强恢复期免疫功能。
?0 cases with human rotavirus(HRV) enteritis were randomly divided into two groups after the detection of immunoglobulin and T-cell group.One group was given interferon apart from the conventional treatment and another group was selected as the control.IgA,IgG,IgM,CD4 and CD4/CD8 were very low but CD8 very high before the treatment of interfer on in both groups(P<0.01). After the treatment,IgA,IgG,IgM,CD4 and CD4/CD8 prominently increased but CD8 remarkably decreased in the tested group.The effective rate in the tested group (90.00%) is much higher than that in the control group (50.00%)with P<0.01. The result suggests that a functional disorder may exist in HRV enteritis and the treatment with a small dosage of interferon will shorten the period of the disease and improve the immune function of the patients.
