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急性冠脉综合征CYP2C19基因多态性与氯吡格雷抵抗的相关性研究 被引量:9

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摘要 目的:探讨CYP2C19基因多态性对急性冠脉综合征患者服用氯吡格雷产生抵抗的相关性。方法:对96例患者术后服用氯吡格雷,提取全血DNA,采用TaqMan探针法扩增CYP2C19多态性位点和流式细胞仪检测血小板反应性指数PRI,以PRI≥50%定义为氯吡格雷抵抗(CR)。观察CYP2C19基因型与临床危险因素对CR及预后不良事件的影响。结果:22.9%的患者发生CR。弱代谢型组比例为11.45%,CR率最高。CYP2C19*2基因型与2型糖尿病是CR的独立危险因素。弱代谢组发生心脏不良事件的频率最高。结论:CR与CYP2C19*2基因型和2型糖尿病密切相关,为判断急性冠脉综合征患者预后提供一定的临床依据。
出处 《陕西医学杂志》 CAS 2016年第5期525-526,529,共3页 Shaanxi Medical Journal
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