摘要
目的:了解氟喹诺酮类抗菌药物引发的药品不良反应(adverse drug reaction,ADR)情况,为临床合理用药提供参考。方法:对宿州市市立医院2014年2月—2015年2月159例氟喹诺酮类抗菌药物引发的ADR情况进行回顾性分析。结果:由左氧氟沙星引发的ADR例次最多(58例,36.48%),其次是环丙沙星(43例,27.04%);静脉滴注引发的ADR高于口服和静脉注射;>60岁患者引发的ADR占62.26%,≤60岁的患者占37.74%,说明年龄越大越易引发ADR。ADR涉及的头疼、失眠等症状较多(39.62%),皮疹、皮肤过敏等症状次之,占22.64%,明显高于其他系统。结论:氟喹诺酮类抗菌药物所引发的ADR,必须引起医务人员高度重视,切实降低其ADR发生率,确保临床用药安全。
OBJECTIVE：To investigate the status of adverse drug reaction（ADR） induced by fluoroquinolone drugs,and to provide reference for the rational drug use in clinic.METHODS：159 cases of ADR induced by fluoroquinolone drugs in Suzhou Municipal Hospital from Feb.2014 to Feb.2015 were retrospectively analyzed.RESULTS：ADR induced by levofloxacin took the lead（58 cases,36.48%）,followed by ciprofloxacin（43 cases,27.04%）.Cases of ADR induced by intravenous drip were higher than that of oral and intravenous injection.Patients with ADR 60 years old was 62.26%,and ≤60 years old was 37.74%,which indicated that elderly patients had a high risk of ADR.The clinical manifestations of ADR were mainly headache and insomnia（39.62%）,followed by skin rash,skin hypersensitivity（22.64%）,significantly higher than other systems.CONCLUSIONS：Great attention should be given to ADR induced by fluoroquinolone drugs,so as to reduce the incidence of ADR and ensure the medication safety in clinic.
出处
《中国医院用药评价与分析》
2016年第4期551-553,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
氟喹诺酮类抗菌药物
不良反应
调查分析
Fluoroquinolone drugs
Adverse drug reactions
Investigation and analysis
