摘要
目的探讨卡马西平对妊娠合并癫痫患者母婴结局的影响及叶酸的干预效果。方法选取2006年5月至2015年6月于本院就诊的妊娠合并癫痫患者56例为研究对象,采用随机数表法将其分为对照组和观察组,每组各28例。对照组患者给予卡马西平,观察组患者在对照组治疗基础上联合服用叶酸。观察两组患者癫痫发作程度、妊娠期并发症发生情况及母婴结局。结果观察组患者癫痫发作频率明显少于对照组(P<0.05);观察组患者妊娠高血压综合征、妊娠期抑郁发生率及围生期癫痫发作次数较对照组明显减少(P<0.05):而两组患者自然流产、前置胎盘、早产发生率比较均无明显差异(P>0.05)。观察组新生儿畸形、低体重儿发生率较对照组明显升高(P<0.05),两组胎儿宫内窘迫、死胎发生率比较均无明显差异(P>0.05)。结论卡马西平可以控制妊娠合并癫痫患者的癫痫发作频率,联合叶酸治疗可以降低胎儿畸形发生率。
Objective To investigate the effect of carbamazepine on maternal and neonatal outcomes of pregnant women with epilepsy and the intervention effect of folic acid.Method A total of 56 pregnant women with epilepsy who received treatment in our hospital from May 2011 to June 2014 were selected and randomly divided into control group and observation group,28 cases in each group.Control group patients were treated with carbamazepine,while observation group patients received folic acid treatment on the base of routine therapy.Observed and compared the epileptic seizures,clinical complications and the maternal and neonatal outcomes between the two groups.Result The incident of epileptic seizure,hypertension syndrome of pregnancy and stnatal depression of observation group was less than control group（P〈0.05）;but there were no differences in spontaneous abortion,placenta placenta,premature birth rate between the two groups（P〉0.05）.The incident of neonatal malformations,and low body weight of observation group was less than control group（P〈0.05）;but there were no differences in stillbirth and fetal distress,premature birth rate between the two groups（P〉0.05）.Conclusion Carbamazepine can control the seizure frequency of epilepsy in pregnancy women,and the combined therapy of carbamazepine and folic acid can reduce the fetal malformation rate.
出处
《中国医学前沿杂志（电子版）》
2016年第4期79-81,共3页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
卡马西平
妊娠
癫痫
叶酸
Carbamazepine
Pregnancy
Epilepsy
Folic acid
