摘要
Objective： To observe the effect of electroacupuncture （EA） and herbal cake-partitioned moxibustion on anxiety and depression in patients with Crohn＇s disease （CD） in remission. Methods： Sixty CD cases were randomly allocated into an EA group （n=30） and an herbal cake-partitioned moxibustion group （n=30） using the random number table by the ratio of 1：1. In addition, 30 healthy subjects were included in a control group. Bilateral Tianshu （ST 25）, Qihai （CV 6） and Zhongwan （CV 12） were used in the EA and herbal cake- partitioned moxibustion groups. The treatment was done 3 times a week, for a total of 12 weeks. The efficacy was evaluated using self-rating anxiety scale （SAS）, self-rating depression scale （SDS） and traditional Chinese medicine （TCM） symptom scores. Results： Before treatment, the SAS and SDS scores in CD patients were remarkably higher than those in healthy subjects. After EA or herbal cake-partitioned moxibustion treatment, the SAS and SDS scores were significantly decreased in both groups, showing significant intra-group differences （P〈0.05）; the symptom scores of abdominal pain （severity, frequency and duration）, bowel sounds/flatus and general fatigue were significantly decreased, showing significant intra-group differences （P〈0.05）; however, there were no between-group statistical differences （P〉0.05）. Conclusion： Both EA and herbal cake-partitioned moxibustion can significantly decrease abnormally high SAS and SDS scores in CD patients as well as TCM symptom scores. The two therapies share similar effects in alleviating common symptoms and improving anxiety and depression.
目的:观察电针和隔药灸对缓解期克罗恩病(Crohn’s disease,CD)患者焦虑和抑郁情绪的影响。方法:将60例符合纳入标准的患者按照1:1比例按随机数字表随机分为电针组和隔药灸组,纳入30例健康受试者作对照。电针组或隔药灸组均选取双侧天枢,气海和中脘,电针组患者采用电针治疗,隔药灸组患者采用隔药灸治疗,每星期治疗3次,共治疗12星期。以自评焦虑量表(self-rating anxiety scale,SAS)、自评抑郁量表(self-rating depression scale,SDS)及中医症状积分为观察指标进行疗效评价。结果:与健康受试者相比,CD患者S AS和S DS评分显著增加。电针和隔药灸治疗后,两组患者S AS和S DS评分均显著降低,与本组治疗前有统计学差异(P<0.05);患者腹痛(程度、频次、时间)及肠鸣矢气、神疲乏力症状积分显著降低,与本组治疗前有统计学差异(P<0.05),两种疗法间差异无统计学意义(P>0.05)。结论:电针和隔药灸均能降低C D患者异常增高的S AS、SDS评分及常见中医症状积分,在缓解临床常见症状的同时改善其焦虑和抑郁情绪,两种疗法作用相当。
基金
supported by National Basic Research Program of China 973 Program(No.2015CB554501,No.2009CB522900)
Shanghai Rising-star Program(No.16QA1403400)
the Program for New Century Excellent Talents in University of Ministry of Education(No.NCET-13-0907)~~
