期刊文献+

整合子与细菌耐药相关性研究进展 被引量:9

Progress on the correlation between integrons and bacterial drug resistance
下载PDF
导出
摘要 整合子是近年来被发现的一种新的遗传结构元件,能够识别外界的耐药基因,可以通过位点特异性重组的方式捕获耐药基因并使其表达;也可以位于质粒或转座子上,作为质粒或转座子的一个组成部分,在转移的过程中使耐药基因在细菌中发生播散。整合子因为与细菌耐药性的产生和传播关系密切而备受各方的关注。 Integron is a mobile gene element being found recently. It could recognize drug resistance gene from outside. It can also recombine exogenous gene and express by site-specific recombination. In addition,integron is located at transposon or plasmid,and by being a part of it transmitting drug resistance gene. Researches on integron are attracting many interests for its importance in the generation of drug resistance and transmission.
出处 《检验医学》 CAS 2016年第4期324-328,共5页 Laboratory Medicine
基金 浙江省自然基金资助项目(Y2110743)
关键词 整合子 耐药基因 传播 Integron Drug resistance gene Transmission
  • 相关文献

参考文献39

  • 1STOKES HW,HALL RM.A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions:integrons[J].Mol Microbiol,1989,3(12):1669-1683.
  • 2HALL RM,STOKES HW. Integrons: novel DNA elements which capture genes by site-specific recombination [J].Genetica,1993,90(2-3):115-132.
  • 3COLLIS CM,HALL RM. Expression of antibiotic resistance genes in the integrated cassettes of integrons [J]. Antimicrob Agents Chemother,1995,39(1):155-162.
  • 4RECCHIA GD,HALL RM. Gene cassettes: a new class of mobile element [J]. Microbiology,1995,141(Pt 12):3015-3027.
  • 5HALL RM,COLLIS CM,KIM MJ,et al. Mobile gene cassettes and integrons in evolution [J].Ann N Y Acad Sci,1999,18:68-80.
  • 6VINUé L,JOVE T,TORRES C,et al.Diversity of class 1 integron gene cassette Pc promoter variants in clinical Escherichia coli strains and description of a new P2 promoter variant[J].Int J Antimicrob Agents,2011,38(6):526-529.
  • 7卓超.细菌基因盒-整合子系统研究进展[J].国外医药(抗生素分册),2002,23(2):57-61. 被引量:10
  • 8COLLIS CM,HALL RM. Site-specific deletion and rearrangement of integron insert genes catalyzed by the integron DNA integrase [J].J Bacteriol,1992,174(5): 1574-1585.
  • 9COLLIS CM,GRAMMATICOPOULOS G,BRITON J,et al. Site-specific insertion of gene cassettes into integrons [J].Mol Microbiol,1993,9(1):41-52.
  • 10COLLIS CM,HALL RM. Gene cassettes from the insert region of integrons are excised as covalently closed circles [J].Mol Microbiol,1992,6(19):2875-2885.

二级参考文献70

共引文献36

同被引文献94

引证文献9

二级引证文献36

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部