摘要
基于基因-体质-证候三者之间的必然联系,提出以体质为中间桥梁连接冠心病证候与基因多态性,通过基因-体质-证候这一研究模式探讨冠心病证候的研究思路。继而分析了体质与冠心病证候关系、冠心病常见体质及常见证候类型的基因多态性研究现状,并进行了相关研究方法的分析,以期为此研究模式提出可行的研究方案。通过冠心病瘀血质、气虚质和痰湿质三种常见体质及血瘀证、痰浊证、痰瘀互结证3种常见证候基因多态性现有研究的分析与综合,提出了可供选择及进一步荟萃分析的候选基因。通过比较候选基因及全基因组研究方法,结合此模式的研究特点提出运用高通量的列阵技术进行候选基因研究。同时,通过分析也发现了样本选择收集、候选基因选择及冠心病作为多基因遗传病之间的问题有待于进一步研究的解决。
Based on the necessary connection among gene,constitution and syndrome,a research method is proposed that constitution as for the intermediate links to study coronary artery disease syndrome and gene polymorphism. And then we analyzed the relationship between constitution and coronary artery disease syndrome and then gene polymorphism research status of common coronary heart disease（ CHD） syndrome and constitution. At the same time,the research methods were analyzed in detail to put forward the feasible research plan. Through the above analysis,we put forward the selection and Meta- analysis of the candidate genes. Combining with the characteristics of this pattern and comparison the methods of candidate genes and genome research,we proposed the use of high- throughput array technology was studied by means of candidate genes. At the same time,the analysis found that the sample collection,choice of candidate genes and coronary heart disease（ CHD） as the complex genetic diseases should be further researched to solve the problems.
出处
《中华中医药学刊》
CAS
北大核心
2016年第5期1114-1117,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家重点基础研究发展计划(973计划)项目(2013CB531704)
辽宁省科学技术计划项目(2014225004)
关键词
冠心病
基因多态性
体质
证候
coronary artery heart disease（CHD）
gene polymorphis
constitution
syndrome
