摘要
目的通过研究101例HIV/HCV共感染患者念珠菌检出情况,分析其可能的相关因素.方法采集101例HIV/HCV共感染患者口腔、皮肤、指甲标本,采用CHROMagar念珠菌显色培养基培养、45℃生长试验及API-20C-AUX鉴定系统鉴定到种,同时进行单因素和多因素分析.结果 101例HIV/HCV共感染患者中有44例(43.6%)检出念珠菌,所分离到的44株念珠菌中,有19株白念珠菌(43.2%),9株近平滑念珠菌(20.5%),8株季也蒙念珠菌(18.2%),1株为热带念珠菌(2.3%),1株克柔念珠菌(2.3%),5株涎沫假丝酵母菌(11.4%),1株产朊假丝酵母(2.3%).通过单因素和多因素分析发现:该人群念珠菌检出率的CD4计数、病毒载量比较差异具有统计学意义(P<0.01).结论 HIV/HCV共感染患者念珠菌主要菌种是白念珠菌、近平滑念珠菌和季也蒙念珠菌;检出率与CD4计数、病毒载量高度相关;检出率可能对HIV/HCV共感染患者判断临床预后有一定参考价值.
Objective To analyze the conceivable correlation factor and significance through investigating detection of candida from 101 HIV/HCV.Method To identify the sample collected from oral cavity,skin,nail of101 coinfection cases with HIV/HCV,by using CHROMagar Candida color medium,45 ℃ growth test,API-20 CAUX identification system.Simultaneously,to search the correlated information of pidemiology,treatment anddetection to progress single actor and multiple factors through the national AIDS comprehensive prevention and control of information system.Results In 101 coinfection cases with HIV/HCV,44 cases（43.6%） were detected with candida.In 44 strains candida,19 strains（43.2%） were C.Albicans,9 strains（20.5%） were C.parapsilosis,8 strains（18.2%） were C.Guilliermondii,1 strain（2.3%） was C.tropicalis,1 strain（2.3%） was C.krusei,5strains（11.4%） were C.zeylanoides,1 strain（2.3%） was C.mycoderma.There was statistical difference in CD4 and viral load through single factor and multiple factors analysis.The detection rate of CD4 and viral load were significantly higher than that of other groups.Conclusion The major strains were C.Albicans,C.parapsilosis,C.Guilliermondii.The detection rate was highly correlated with CD4 number and viral load.It has certain reference value to prejudge prognosis of clinical virology and immunology of HIV/HCV coinfection cases.
出处
《北华大学学报（自然科学版）》
CAS
2016年第3期355-358,共4页
Journal of Beihua University（Natural Science）
基金
吉林省科技发展计划项目(20120750)
吉林省卫生厅基金课题(2011z057)
上海市卫生局基金课题(20134362)
上海市复旦大学附属中山医院青浦分院院级课题(QYM2012-09)
