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康摩膏的基质及促渗透剂考察 被引量:6

Prescription Research of Kangmo Paste
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摘要 目的:优选康摩膏中基质类型及复合促渗透剂,为改善该制剂的透皮扩散速率提供参考。方法:采用HPLC测定芍药苷含量,流动相甲醇-0.1%冰乙酸(30∶70),流速0.9 m L·min^(-1),检测波长234 nm。选择SD小鼠腹部皮肤,通过Franz扩散池法进行体外透皮吸收试验,以芍药苷12 h累积渗透量及渗透率为指标,评价药物在不同类型基质中的释放性能和透皮性能,优选基质类型;通过星点设计-效应面法考察复合促渗剂氮酮、丙二醇对康摩膏中芍药苷体外经皮渗透的影响,优选最佳的透皮吸收促进剂组合。结果:选择O/W乳剂型基质,最佳促渗透剂组合为2.4%氮酮和1.6%丙二醇,芍药苷在12 h的累积渗透率72.20%。结论:优选的基质及促渗透剂可明显提高康摩膏的透皮吸收性能,可为该制剂的工业化生产提供参考。 Objective: To observe enhancement of transdermal diffusion rate of Kangmo paste by screening type of substrates and compound penetration enhancers. Method: HPLC was adopted to determine the content of paeoniflorin by taking methanol-0. 1% glacial acetic acid( 30 ∶ 70) as mobile phase and detection wavelength of 234 nm. Utilized skin on the back of SD rats,in vitro percutaneous absorption test was used by Frans diffusion cell method,with cumulative osmotic quantity in 12 h and penetration rate as indexes,which was used to evaluate release and transdermal performance of drug in different types of substrates,in order to select substrate type. Effects of composite permeability dose of azone and propylene glycol on in vitro percutaneous penetration of paeoniflorin in Kangmo paste were investigated by central composite design-response surface methodology. Result: Matrix of O/W emulsion was chosen; when accumulative release rate of paeoniflorin was72. 20% in 12 h,combination of penetration enhancer was 2. 4% azone and 1. 6% propylene glycol. Conclusion:This optimized substrate and penetration enhancer can significantly improve transdermal rate constant of Kangmo paste.
出处 《中国实验方剂学杂志》 CAS CSCD 北大核心 2016年第10期15-19,共5页 Chinese Journal of Experimental Traditional Medical Formulae
基金 郑州市科技局普通科技攻关项目(10PTGS485-9)
关键词 康摩膏 经皮给药 基质 促渗透剂 芍药苷 丙二醇 Kangmo paste transdermal administration substrate penetration enhancers paeoniflorin propylene glycol
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