摘要
目的研究并探讨不同梅毒血清检测方法在产前梅毒常规筛查中的应用效果。方法于2014年1月-2015年6月,选取在我院进行产前梅毒常规筛查的500例孕妇进行研究,分别采用梅毒螺旋体明胶凝集试验（TPPA法）、免疫胶体金法、甲苯胺红不加热血清反应素试验（TRUST法）对梅毒进行检测,对比TPPA法、免疫胶体金法、TRUST法、三种方法联合检测的敏感度、特异度、准确性、阳性预测值以及阴性预测值。结果 500例进行产前梅毒常规筛查的孕妇中,有448例孕妇被确诊为梅毒阳性,52例孕妇为阴性。三种梅毒血清学检测方法的敏感度、特异度、准确性、阳性预测值以及阴性预测值均不存在统计学差异（P〉0.05）,但三种检测方法联合检测的敏感度、特异度、准确性、阳性预测值以及阴性预测值均明显高于单一的检测方法（P〈0.05）。结论在产前梅毒筛查中,TPPA法、TRUST法以及胶体金法具有其各自的优势,三种方法进行联合检测可提高梅毒检出率,产前梅毒筛查时可进行联合检测。
Objective To study and discuss the application effect of different methods of syphilis serum detection in routine screening of prenatal syphilis. Methods In January 2014- June 2015,500 cases pregnant women for routine prenatal syphilis screening in our hospital were selected, the syphilis was detected by the test of syphilis（TPPA）, immune colloidal gold method, and the non heated serum reaction element test（TRUST method）, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value were compared between TPPA method, immune colloidal gold method, TRUST method and three methods of combined detection. Results 500 cases of prenatal syphilis screening of pregnant women, 448 cases of pregnant women were diagnosed with syphilis, 52 cases of pregnant women were negative. There was no significant difference in the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of the serological detection methods of the three kinds of syphilis（P〈0.05）, but the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of combined detection of three kinds of detection methods were significantly higher than that of single detection method（P〉0.05）. Conclusion In the antenatal syphilis screening and TPPA and trust and colloidal gold method with their respective advantages and three methods of joint detection can improve the detection rate of syphilis, prenatal syphilis screening can be joint detection.
出处
《中国医药科学》
2016年第7期166-168,208,共4页
China Medicine And Pharmacy
基金
广东省珠海市科技计划项目(02651011140620049)
关键词
产前筛查
梅毒
血清学检测
诊断
Prenatal screening
Syphilis
Serological test
Diagnosis
