摘要
目的分析冠状动脉扩张(CAE)患者胰岛素敏感性与CAE病变程度的相关性。方法选取96例CAE患者作为研究对象,检测稳态模型胰岛素抵抗指数(HOMA-IR)指数并作为分组依据,分为冠脉扩张合并胰岛素抵抗(IR-CAE)组(57例)与冠脉扩张合并胰岛素敏感(IS-CAE)组(39例)。比较两组的一般指标及生化指标差异性,以及CAE病变程度的差异性。应用Pearson相关分析HOMA-IR指数与CAE病变程度的相关性,应用多元Logistic回归分析各种指标与CAE发生的危险因素。结果与IR-CAE组相比,IS-CAE组患者的BMI、腹围、收缩压、舒张压、空腹胰岛素(FINS)、总胆固醇、三酰甘油均显著较低(P<0.05),而高密度脂蛋白胆固醇显著较高(P<0.05)。两组CAE病变严重程度差异有统计学意义(P<0.05)。Pearson相关分析显示HOMA-IR指数与CAE病变程度呈正相关(r=0.703,P=0.025)。多元Logistic回归分析显示,FINS及HOMA-IR指数为CAE发生的危险因素(P<0.05)。结论 CAE患者胰岛素敏感性越差,其CAE病变程度越严重。
Objective To analyze the correlation of insulin sensitive level and the degree of coronary artery ectasia（CAE）in patients with CAE.Methods A total of 96 cases of patients with CAE were collected to research and divided into two groups according to HOMA-IR index,which were IR-CAE group（57cases）and IS-CAE group（39cases）.The normal and biochemical indexes of two groups were compared and so as to the degrees of CAE.The correlations of HOMA-IR index and the degrees of CAE were evaluated by Pearson correlation analysis.The risk factors of CAE in patients were confirmed by multivariate Logistic analysis.Results Compared to IR-CAE group,the indexes of BMI,AG,SBP,DBP,FINS,TC,TG in the IS-CAE group were lower（P〈0.05）,and the HDL-C of IS-CAE group were higher（P〈0.05）.There was significant difference in the degree of CAE between two groups（P〈0.05）The positive correlations of HOMA-IR index and the degree of CAE were confirmed by Pearson correlation analysis（r=0.703,P=0.025）.Logistic analysis showed that the FINS and HOMA-IR were independent risk factors to the degree of CAE.Conclusion The negative correlation of insulin sensitive level and the degree of CAE was confirmed.
出处
《重庆医学》
CAS
北大核心
2016年第14期1912-1914,共3页
Chongqing medicine
基金
湖南省卫生厅科研基金资助项目(B2012-049)
