摘要
目的了解肾病患者医院感染病原菌的分布及耐药性情况,为临床合理选择抗菌药物提供参考。方法通过病原菌分离鉴定和药敏试验方法,对某医院肾移植中心住院患者送检临床标本进行检测和耐药性评估。结果从某医院84例医院感染患者送检标本中,共检出病原菌70株,检出率为83.33%。在检出的70株病原菌中,革兰阴性杆菌、革兰阳性球菌和真菌的构成比依次为71.4%、21.5%和7.1%。肾病患者医院感染病原菌主要分离自痰液、中段尿和血液标本,提示以呼吸道、泌尿道和血液相关感染为主。临床分离的革兰阴性菌耐药率较高且普遍,革兰阳性菌对青霉素、红霉素和苯唑西林等抗菌药物耐药率较高。结论该医院住院肾病患者医院感染主要病原菌为革兰阴性杆菌,其中多重耐药菌株比例较高,提示按药敏试验结果合理选择抗菌药物为首要防控对策。
Objective To understand the distribution and drug resistance of pathogenic bacteria of hospital infection in pa- tients with renal disease, and provide reference for rational selection of antibiotics in clinic. Methods Pathogenic bacteria isolation ,identification and drug sensitivity test method were used to test samples of patients of kidney transplantation and e- valuate drug resistance. Results 70 strains of pathogenic bacteria were detected out from the specimens of 84 cases of hos- pital patients with nosocomial infection,the detection rate was 83.33%. The composition ratio of Gram negative bacilli, Gram positive bacteria and fungi were 71.4%, 21.5 % and 7.1%, respectively. The main source of samples were sputum, u- rine and blood samples, which means the main infections sites were respiratory tract, urinary tract and blood related. Gram - negative bacteria had high resistance rate to most antimicrobial drugs, and the resistance rate of Gram - positive bacteria to penicillin, erythromycin and penicillin were high. Conclusion The main pathogenic bacteria in renal transplantation center were Gram - negative bacilli with multiple drug resistance. Clinical doctors should choose antibiotics based on sencitiutytest results to prevent hospital infection.
出处
《中国消毒学杂志》
CAS
北大核心
2016年第5期416-418,共3页
Chinese Journal of Disinfection
关键词
肾病患者
医院感染
病原菌
耐药性
防控对策
renal transplantation
hospital infection
pathogenic bacteria
drug resistance
countermeasures of control and pre-vention
