摘要
用前端聚合法制备了聚(N-异丙基丙烯酰胺)/多壁碳纳米管(PNIPAM/MWCNTS)复合水凝胶,对产物的微观形貌、温敏性、力学性能和释药性能进行了研究。结果表明,PNIPAM/MWCNTS复合水凝胶具有温度敏感性,MWCNTS的加入不影响水凝胶的低临界转变温度,随MWCNTS含量增加,水凝胶吸水能力降低,力学强度显著提高,当MWCNTS的含量由0%增至10%时,水凝胶的压缩强度从88 k Pa增加到666 k Pa。复合水凝胶具有良好的药物缓释性能。
Poly（ N-isopropylacrylamide / carbon nanotubes）（ PNIPAM / MWCNT） composite hydrogels were prepared by frontal polymerization. The morphology,thermosensitivity,mechanical properties and drug release properties of PNIPAM / MWCNT hydrogel were examined. The results show that the PNIPAM / MWCNTS hydrogels are temperature-sensitive. The incorporation of MWCNTS does not influence the lower critical solution temperature（ LCST） of hydrogel but reduces its swelling abilities. MWCNTS improve the mechanical properties of PNIPAM / MWCNTS hydrogel. When the content of MWCNTS increases from 0% to 10%,the compressive strength of hydrogel is improved form 88 k Pa to 666 k Pa. The composite hydrogels show excellent drug release properties.
出处
《高分子材料科学与工程》
EI
CAS
CSCD
北大核心
2016年第5期134-138,共5页
Polymer Materials Science & Engineering
基金
国家自然科学基金资助项目(50772013)
2011年度河南省高等学校青年骨干教师资助计划(2011GGJS-168)
2012年度河南省科技厅科技攻关项目(122102310430)
关键词
聚N-异丙基丙烯酰胺
碳纳米管
复合水凝胶
前端聚合
药物缓释
力学性能
poly（N-isopropylacrylamide / carbon nanotubes）
carbon nanotubes
composite hydrogels
frontal polymerization
drug release properties
mechanical properties
