摘要
目的探讨宁泌泰胶囊联合帕珠沙星治疗泌尿系统感染的临床疗效。方法选取2015年1月—2016年1月黄梅县中医医院收治的泌尿系统感染患者112例,按照治疗方法的差别分成对照组和治疗组,每组各56例。对照组静脉滴注注射用甲磺酸帕珠沙星,0.3 g加入250 m L生理盐水,2次/d。治疗组在对照组治疗的基础上口服宁泌泰胶囊,4粒/次,3次/d。两组均连续治疗2周。观察两组的临床疗效,同时比较两组患者症状缓解时间、消失时间及尿常规恢复时间;比较两组治疗前后尿细菌学的变化情况。结果治疗后,对照组和治疗组的总有效率分别为82.14%、94.64%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组患者临床症状缓解时间、症状消失时间和尿常规恢复时间均显著短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者尿白细胞镜检、尿细菌培养均较治疗前显著降低,同组治疗前后差异有统计学意义(P<0.05);治疗后治疗组这些指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论宁泌泰胶囊联合帕珠沙星治疗泌尿系统感染具有较好的临床疗效,可明显缩短临床症状改善时间,降低尿白细胞镜检和尿培养细菌数量,具有一定的临床推广应用价值。
Objective To evaluate the clinical efficacy of Ningmitai capsules combined with pazufloxacin in treatment of urinary tract infection. Methods Patients （112 cases） with urinary tract infection in Huangmei County Hospital of TCM from January 2015 to January 2016 were enrolled in this study. According to the different treatment plans, patients were divided into control group and treatment group, and each group had 56 cases. The patients in the control group were iv administered with Pazufloxacin Mesylate for injection, 0.3 g added into normal saline 250 mL, once daily. The patients in the treatment group were po administered with Ningmitai Capsules on the basis of control group, 4 grains/time, three times daily. The patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the symptoms relief time, disappearing time and routine urine recovery time in two groups were compared. The changes of urinary bacteriology in two groups before and after the treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 82.14% and 94.64%, respectively, and there were differences between two groups （P 〈 0.05）. After treatment, the symptoms relief time, disappearing time and routine urine recovery time in treatment group were significantly shorter than those in the control group, with significant difference between two groups （P 〈0.05）. After treatment, urinary leukocyte microscopy and urine bacteria culture in two groups were significantly decreased, and the difference was statistically significant in the same group （P 〈 0.05）. After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups （P 〈 0.05）. Conclusion Ningmitai capsules combined with pazufloxacin has clinical curative effect in treatment of urinary tract infection, and can obviously shorten the improved time of clinical symptoms, also can reduce microscopic examination of the urine leukocyte and urine culture bacteria, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2016年第4期488-491,共4页
Drugs & Clinic
关键词
宁泌泰胶囊
注射用甲磺酸帕珠沙星
泌尿系统感染
Ningmitai Capsule
Pazufloxacin Mesylate for injection
urinary tract infection
