摘要
目的 研究类风湿关节炎 (RA)患者血清白细胞介素 (IL) 6、皮质醇节律及其临床意义。方法 36例RA患者分别于 8:0 0、12 :0 0、16 :0 0、2 0 :0 0、0 :0 0、4 :0 0用双抗体夹心酶联免疫吸附试验 (ELISA)检测其血清IL 6水平 ,用放射免疫法 (RIA)测定皮质醇。结果 36例RA患者皮质醇分泌有明显节律 ,但与正常对照组相比 ,其峰值提前 ,出现于凌晨 4点。血清IL 6水平高于对照组 (P <0 0 1) ,也存在昼夜节律。IL 6峰值出现在皮质醇峰值之前。经治疗病情稳定后 ,RA患者血清IL 6水平恢复或接近正常 ,IL 6与皮质醇节律紊乱得以纠正。相关性分析显示 ,RA患者血清IL 6水平与血沉 (ESR) (P <0 0 1,r=0 6 6 )、C反应蛋白 (CRP) (P <0 0 1,r =0 71)、皮质醇 (P <0 0 5 ,r=0 5 8)呈正相关。结论 RA患者血清IL 6增高 ,IL 6与皮质醇存在昼夜节律紊乱 。
Objective To investigate the circadian variation of serum interleukin 6 (IL 6) and cortisol and their clinical value in rheumatoid arthritis (RA) patients.Methods Serum IL 6 levels were detected in 36 untreated RA patients at 8:00,12:00,16:00,20:00,0:00 and 4:00 with ELISA,and serum cortisol levels were measured by radioimmunoassay (RIA).Results There was pronounced circadian variation of serum cortisol levels in 36 untreated RA patients,but the peak was at 4:00 and earlier than that of controls.The level of IL 6 was signficantly higher in patients than in healthy people ( P <0 01).There was also pronounced circadian variation of serum IL 6 levels.The peak of serum IL 6 appeared before that of cortisol.Treated RA patients had significantly reduced serum IL 6 compared with untreated RA patients, and it recovered or neared to the normal.Pronounced circadian disorder of serum IL 6 and cortisol levels recovered there was a positive correlation between serum levels of IL 6 and ESR ( P <0 01, r =0 66),CRP ( P <0 01, r =0 71) and cortisol( P <0 05, =0 58) Conclusion Serum IL 6 levels are significantly increased in the RA patients,compared to control subjects.Serum IL 6 and cortisol levels show a pronounced circadian variation.These findings have an important implication in the pathogensis and development of RA.It is important to further study the pathophysiologic significance of IL 6 and cortisol in RA.
出处
《中华风湿病学杂志》
CAS
CSCD
2002年第4期252-254,共3页
Chinese Journal of Rheumatology
