摘要
根据活性基团拼接原理,以烯草酮为先导化合物,通过修饰其肟醚位,引入具有除草活性的环苯草酮肟醚结构,设计并合成了一个新型的环己烯酮衍生物(7)。以对氯苯酚为原料,经取代、还原、卤代、肟醚化、水解等5步反应制得O-[2-(4-氯苯氧基)丙基]-羟胺盐酸盐(5);5与5-[2-(乙硫基)丙基]-3-羟基-2-丙酰基-2-环己烯-1-酮反应合成了7,其结构经~1H NMR,^(13)C NMR,IR,ESI-MS和元素分析表征。
Herbicidal activity structure of profoxydim oxime-ether was introduced by modifying the oxime-ether structure of clethodim,according to the active-group combination principle. O-[2-（ 4-chlorophenoxy） propyl]-hydroxylamine hydrochloride（ 5） was obtained by substitution,reduction,halogenation,oxime etherification and hydrolysis,using p-chlorophenol as starting materials. A novel cyclohexanediones derivative was designed and synthesized by the reaction of 5 with 5-[2-（ ethylthio） proplyl]-3-hydroxy-2-propionyl-2-cyclohexen-1-one. The structure was characterized by^1 H NMR,^（13）C NMR,IR,ESI-MS and elemental analysis.
出处
《合成化学》
CAS
CSCD
2016年第5期422-425,共4页
Chinese Journal of Synthetic Chemistry
基金
企业委托"药物创制研究开发"项目(H140192)
关键词
烯草酮
肟醚
环己烯酮
活性基团拼接原理
合成
clethodim
oxime ether
cyclohexanedione
active-group combination principle
synthesis
