急性冠状动脉综合征患者血浆网膜素-1、内脏脂肪特异性丝氨酸蛋白酶抑制剂水平变化被引量：7

Analysis of Plasma Levels of Omentum-1 and Vaspin in Patients With Acute Coronary Syndrome

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摘要目的:观察急性冠状动脉综合征(ACS)患者血浆网膜素-1(Omentin-1)、内脏脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)水平的变化。方法:选择2013-05至2013-09在本院确诊为ACS的100例患者为ACS组,其中男性52例,女性48例;另选同期住院行冠状动脉造影除外冠心病的88例患者作为对照组,男性47例,女性41例。采用酶联免疫吸附法测定冠心病组及对照组的Omentin-1、Vaspin浓度。结果:ACS组患者血浆Omentin-1水平低于对照组(t=2.718,P<0.05)、Vaspin水平低于对照组(t=2.416,P<0.05);相关分析显示,ACS患者Omentin-1水平与总胆固醇(r=-0.702,P<0.05)、C反应蛋白(r=-0.714,P<0.05)等呈负相关;Vaspin水平与总胆固醇(r=-0.655,P<0.05)、C反应蛋白(r=-0.587,P<0.05)等呈负相关关系;Omentin-1水平与Vaspin水平呈正相关(r=0.643,P<0.05);多元线性逐步回归分析显示Omentin-1、Vaspin均可能受C反应蛋白、总胆固醇、LDL-C水平的影响。结论:ACS患者存在Omentin-1水平及Vaspin水平的降低,此外,Omentin-1与Vaspin可能与脂代谢有关。 Objective： To observe the changes of plasma levels of omentin-1 and vaspin in patients with acute coronary syndrome（ACS）. Methods： Our research included in 2 groups： ACS group, the patients with confirmed diagnosis in our hospital from 2013-05 to 2013-09, n=100 including 52 male, 48 female and Control group, the patients with simultaneous coronary angiography excluded CAD, n=88. Plasma levels of omentin-1 and vaspin were examined by ELISA and the differences were compared between 2 groups.Results： Plasma levels of omentin-1 and vaspin in ACS group were lower than Control group（t=2.718, P〈0.05） and（t=2.416, P〈0.05）. Correlation analysis presented that in ACS group, omentin-1 level was negatively related to total cholesterol（TC）（r=-0.702, P〈0.05） and C-reactive protein（CRP）（r=-0.714, P〈0.05）; vaspin was negatively related to TC（r=-0.655, P〈0.05） and CRP（r=-0.587, P〈0.05）; Omentin-1 was positively related to vaspin（r=0.643, P〈0.05）. Multiple linear stepwise regression analysis showed that plasma levels of omentin-1 and vaspin might be affected by CRP, TC and LDL-C.Conclusion： ACS patients had decreased plasma levels of omentin-1 and vaspin; in addition, omentin-1 and vaspin might be involved in lipid metabolism.

作者王馨张琳张晓东安健

机构地区山西省心血管病医院心内科

出处《中国循环杂志》 CSCD 北大核心 2016年第5期446-448,共3页 Chinese Circulation Journal

基金山西省科技厅青年基金(2012021035-2)

关键词急性冠状动脉综合征血浆网膜素-1 内脏脂肪特异性丝氨酸蛋白酶抑制剂 Acute coronary syndrome Omentin-1 Vaspin

分类号 R543 [医药卫生—心血管疾病]

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