摘要
自噬是细胞在能量缺乏等代谢压力下,通过包裹细胞内的蛋白、细胞器和胞质,实现细胞成分的循环利用,从而维持细胞的正常代谢和生存。近期的研究表明,自噬在肿瘤的发生、发展和治疗中具有重要意义,既可以诱发肿瘤细胞死亡又可以介导死亡逃避。中医药既可以调控肿瘤细胞的自噬性死亡,又可以影响其保护性自噬,为中医药抗肿瘤研究提供了新的思路。
Autophagy is a cellular physiological pathway in which damaged or superfluous proteins and organelles are cleared. Autophagy can also maintain homeostasis and viability of cells under metabolic stress by the recycling of these intracellular constituents. Recent studies have shown that autophagy plays an important role in the pathogenesis, development and treatment of tumor, such as induces apoptosis of tumor cells or promotes the escape from cell death. Traditional Chinese medicine (TCM) regulates autophagic cell death (ACD), on the other hand, TCM can impact on the protective autophagy of tumor cells. All of these provide new ideas for research of anti-tumor mechanism.
作者
李黎
季漪
李文婷
马艳霞
李沐涵
吴勉华
LI Li;JI Yi;LI Wen-ting;MA Yan-xia;LI Mu-han;WU Mian-hua(The First Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, China;Collaborative Innovation Center of Chinese Medicine in Prevention and Treatment of Cancer of Jiangsu Province, Nanjing 210023, China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2019年第1期223-225,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.81503535
No.81673559
No.81573910)~~
关键词
自噬
中医药
恶性肿瘤
Autophagy
TCM
Malignant tumor
