摘要
目的:比较针刺结合康复训练与单纯康复训练治疗缺血性脑卒中后吞咽障碍的疗效差异及其对血清脑源性神经营养因子(BDNF)的影响。方法:采用SPSS 20.0软件将69例缺血性脑卒中吞咽障碍患者随机分为对照组(35例)和观察组(34例)。观察组采用针刺结合康复训练,对照组仅采用康复训练,均为每日1次,每周5次,共治疗8周。比较两组治疗前后洼田饮水试验分级、标准吞咽功能评价量表(SSA)评分、总有效率及血清BDNF水平。结果:洼田饮水试验,两组患者治疗后较治疗前均有改善(P<0.05),治疗后两组之间差异无统计学意义。观察组总有效率为97.06%,对照组为88.57%,差异具有统计学意义(P<0.05)。两组患者治疗后SSA评分较治疗前均有降低(P<0.05),且观察组低于对照组(P<0.05)。两组患者治疗后血清BDNF水平较治疗前均有升高(P<0.05),且观察组高于对照组(P<0.05)。结论:针刺结合康复训练能有效改善缺血性中风后患者的吞咽障碍,疗效优于单纯康复训练组,血清BDNF水平的升高可能是其康复的潜在机制之一。
Objective:To compare the effects of acupuncture combined with rehabilitation training with single rehabilitation training on dysphagia and serum brain derived neurotrophic factor(BDNF)in patients with ischemic stroke.Methods:A total of 69 patients were randomly divided into control group(35 cases)and observation group(34 cases)with the SPSS 20.0.The observation group was treated with acupuncture combined with rehabilitation training,while the control group was treated with rehabilitation training only.All the treatments were served once a day,five days per week,and lasted for eight weeks.The water swallowing test,standardized swallowing assessment(SSA),total effective rate and the serum BDNF level were evaluated for two groups.Results:In terms of the water swallowing test,all patients in two groups had improved after treatment(P<0.05),but there was no statistical significance between two groups after treatment.The total effective rate of observation group and control group were 97.06%and 88.57%respectively,and there was significant difference between two groups(P<0.05).Moreover,all patients in two groups had decreased in SSA after treatment(P<0.05),and the SSA of the observation goup was lower than that of the control group(P<0.05).In addition,serum BDNF levels increased in both groups after treatments(P<0.05),the serum BDNF level of the observation group was higher than that of the control group(P<0.05).Conclusion:Acupuncture combined with rehabilitation training can effectively improve the dysphagia of patients after ischemic stroke,and its effect is better than simple rehabilitation training,and the increased serum BDNF level may be one of the potential mechanisms of rehabilitation.
作者
黄健婷
罗晓舟
崔韶阳
许明珠
唐纯志
HUANG Jian-ting;LUO Xiao-zhou;CUI Shao-yang;XU Ming-zhu;TANG Chun-zhi(Clinical Medical College of Acupuncture,Moxibustion and Rehabilitation,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Shenzhen Hospital of Guangzhou University of Chinese Medicine,Shenzhen 518034,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2019年第2期830-833,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家重点基础研究发展计划(973计划)(No.2012CB518504)
广东省中医药管理局课题项目(No.20161215)
深圳市科技创新委员会课题(No.JCYJ20160425151844396)~~
关键词
针刺
康复训练
缺血性脑卒中
吞咽障碍
脑源性神经营养因子
Acupuncture
Rehabilitation training
Ischemic stroke
Dysphagia
Brain derived neurotrophic factor
