1型糖尿病患儿全视野闪光视网膜电图反应特征被引量：1

Features of full field electroretinogram responses in children with early type 1 diabetes

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摘要目的观察1型糖尿病（T1D）患儿全视野闪光视网膜电图（FF-ERG）反应特征。方法回顾性临床病例研究。T1D患儿41例（T1D组）及轻度屈光不正儿童25名（对照组）纳入研究。所有T1D患儿经视力、屈光度、眼压、裂隙灯显微镜、眼底彩色照相、间接检眼镜及光相干断层扫描检查排除糖尿病视网膜病变。所有受检儿均由同一位有经验的技师进行FF-ERG检查。包括暗适应视杆细胞反应0.01（r-b 0.01）、暗适应最大混合反应3.0（mix-a 3.0、mix-b 3.0）、暗适应最大混合反应10.0（mix-a 10.0、mix-b 10.0）、暗适应3.0振荡电位2（OP2）、明适应视锥细胞反应3.0（c-a 3.0、c-b 3.0）及30 Hz闪烁光反应（30 Hz FP）的振幅、潜伏期。对比分析两组受检儿FF-ERG各反应振幅及潜伏期差异。结果与对照组比较，T1D组患儿各反应振幅降低，潜伏期延长。两组受检儿各反应振幅比较，除r-b 0.01振幅（t=-0.228，P＞0.05）之外，其余各反应振幅之间的差异均有统计学意义（t=-1.664、-3.645、-4.324、-6.123、-5.846、-12.900、-14.400、-5.230，P＜0.05）。两组受检儿各反应潜伏期比较，mix-b 3.0、mix-b 10.0、c-b 3.0及OP2潜伏期之间的差异有统计学意义（t=5.242、2.879、5.378、3.506，P＜0.05）；r-b 0.01、mix-a 3.0、mix-a 10.0、c-a 3.0、30 Hz FP潜伏期之间的差异无统计学意义（t=2.331、1.677、0.557、0.840、0.064，P＞0.05）。结论 T1D组患儿较正常儿童FF-ERG反应振幅降低，潜伏期延长。 Objective To observe the features of the full field electroretinogram （FF-ERG） in type 1 diabetes （T1D） children without diabetic retinopathy （DR）. Methods Retrospective case study. Forty-one T1D children and 25 age-matched normal controls underwent a complete ophthalmic examination, including best-corrected visual acuity, refraction, intraocular pressure, slit lamp, fundus photography, indirect ophthalmoscopy, and spectral domain optical coherence tomography to exclude DR. All FF-ERG tests were performed by an experienced technician. The ERG series includes six protocols： dark-adapted 0.01 ERG （r-b 0.01）; dark-adapted 3 ERG （mix-a 3.0, mix-b 3.0）; dark-adapted 10 ERG （mix-a 10.0, mix-b 10.0）; dark-adapted oscillatory potentials （OPS）; light-adapted 3 ERG （c-a 3.0, c-b 3.0）; light-adapted 30 Hz flicker （30 Hz FP） ERG. To compare the amplitudes and implicit times of the FF-ERG between the T1D and control group children. Results Compared with the control subjects , the FF-ERG amplitudes decreased and the implicit times increased in T1D. Except for r-b 0.01 （t=-0.228, P〉0.05）, the amplitudes of other FF-ERGs were all significantly attenuated （t=-1.664, -3.645, -4.324, -6.123, -5.846, -12.9, -14.4, -5.23; P〈0.05） in T1D children. The implicit times of mix-b 3.0, mix-b 10.0, c-b 3.0 and OP2 significantly increased （t=5.242, 2.879, 5.378, 3.506; P〈0.05）. The implicit times of r-b 0.01, mix-a 3.0, mix-a 10.0, c-a 3.0 and 30Hz FP changes were not significantly （t=2.331, 1.677, 0.557, 0.84, 0.064; P〉0.05）. Conclusion The FF-ERG amplitudes decreased and implicit times increased in T1D children compared with the control normal subjects.