摘要
目的：探讨熊去氧胆酸（UDCA）联合铝碳酸镁及多潘立酮对胃癌远端胃切除术后胆汁反流性残胃炎的治疗效果。方法将70例胃癌远端胃切除术后胆汁反流性残胃炎患者随机分为治疗组和对照组，每组35例。治疗组给予熊去氧胆酸软胶囊，400 mg，睡前1次＋铝碳酸镁片，1000 mg，3次/ d ＋多潘立酮，10 mg，3次/ d；对照组给予铝碳酸镁片，1000 mg，3次/ d ＋多潘立酮，10 mg，3次/ d。两组疗程均为4周。评估患者5种主要临床症状（中上腹烧灼感、腹胀、口苦、恶心、呕吐胆汁）治疗后缓解情况，评估治疗后胃镜及活检组织病理改善情况。结果治疗组患者中上腹烧灼感、腹胀、口苦、恶心及呕吐胆汁的缓解率分别为80.0%、88.6%、85.7%、74.3%、91.4%，对照组分别为57.1%、65.7%、62.9%、48.6%、68.6%，两组比较差异均有统计学意义（P〈0.05）；治疗组胃镜改善率为85.7%，对照组为60.0%，两组比较差异有统计学意义（P〈0.05）；治疗组活检组织病理改善率为94.3%，对照组为68.6%，两组比较差异有统计学意义（P〈0.05）。结论熊去氧胆酸联合铝碳酸镁及多潘立酮的治疗方案不仅可有效缓解胃癌远端胃切除术后胆汁反流性残胃炎患者的临床症状，并且能够改善胃镜征象及活检组织病理的严重程度，值得临床推广。
Objective To investigate the effect of ursodeoxycholic acid（UDCA）combined with hydrotalcite and domperidone on residual gastritis of bile reflux after distal gastrectomy due to gastric cancer. Methods Seventy patients with residual gastritis of bile reflux were randomly divided into the treatment group and the control group,with 35 patients in each group. The patients in treatment group were given UDCA,400 mg,qn ＋ hydrotalcite,1000 mg,tid ＋ domperi-done,10 mg,tid. The patients in control group were given hydrotalcite,1000 mg,tid ＋ domperidone,10 mg,tid. The treatment lasted for 4 weeks in both groups. The remission rate of 5 major clinical systoms（burning in epigastrium,abdomi-nal distension,bitter taste,nausea,bilious vomiting）were assessed,the improvement of gastroscope and histopathology were also evaluated. Results Clinical systoms：the remission rates of the treatment group（burning in epigastrium,abdom-inal distension,bitter taste,nausea,bilious vomiting）were 80. 0% ,88. 6% ,85. 7% ,74. 3% ,91. 4% ,and those in the control group were 57. 1% ,65. 7% ,62. 9% ,48. 6% ,68. 6% ,there were significant differences between the two groups （P〈 0. 05）. Gastroscope and histopathology：the improvement rate of the treatment group was better than that in the con-trol group,the difference was significant（P〈 0. 05）. Conclusions Ursodeoxycholic acid combined with hydrotalcite and domperidone can not only rapidly relieve clinical systoms,but also significantly reduce bile reflux,gastric mucosal damage and histopathological changes.
出处
《中国实用医刊》
2016年第7期7-9,共3页
Chinese Journal of Practical Medicine
关键词
胃癌
远端胃切除术
胆汁反流
熊去氧胆酸
Gastric cancer
Distal gastrectomy
Bile reflux
Ursodeoxycholic acid
