摘要
铅是一种常见的广泛存在于环境中的重金属污染物,对全身多个系统有毒性作用。为尝试解释铅对机体免疫系统的毒作用及其机制,近20年来众多学者做了大量流行病学调查及动物实验研究。结果提示,铅对机体的天然免疫系统和调节性免疫系统均有一定的毒性,包括铅引起巨噬细胞的吞噬能力下降,提高巨噬细胞内的氧化应激水平,抑制细胞免疫,促进体液免疫等。国内外学者对铅的免疫毒性及其机制方面的资料已有部分报道,本文在此基础上就相关研究进展进行综述。
Lead, a common heavy metal pollutant existent in the environment, is toxic to multiple organ systems of the body. To explain the toxic effects and mechanism of lead on immune system, various studies including epidemiological investigations and animal experiments have been conducted over past two decades. Accumulating evidence indicates that lead is immunotoxic and influences both innate and adaptive immunity. Lead decreases the phagocytic activity and increases the oxidative stress of macrophages. Lead also inhibits cell-mediated immunity and promotes humoral immunity. This review summarized related recent literatures.
出处
《环境与职业医学》
CAS
CSCD
北大核心
2016年第5期523-527,共5页
Journal of Environmental and Occupational Medicine
关键词
铅
免疫系统
天然免疫
调节性免疫
免疫毒性
lead
immune system
innate immunity
adaptive immunity
immune toxicity
