摘要
将老年大白鼠(24个月)左侧海马繖部分切断,建立基底前脑胆碱能损害的老年痴呆动物模型。予侧脑室注射神经生长因子(NGF),分别在用药后15天和30天测隔区和海马胆碱乙酰转移酶(ChAT)活性。以正常鼠组和细胞色素C注射组作为对照。损害后隔区和同侧海马ChAT活性显著减少;NGF15天治疗组,隔区和损害对侧海马酶活性显著增加,是正常组的130%;30天治疗组,同侧海马酶活性比细胞色素C组增加48%。结果表时,NGF对老年鼠基底前脑胆碱能系统损害的治疗是有效的。本文还讨论了NGF在损害后急、慢性期的作用机制。
Nerve growth factor (NGF) was in-jected intraventricularly into the aged(24 months) rats with unilateral lesionsof the lateral fimbria. The activities ofcholine acetyltransferase (CHAT) weredetermined in the septum and hippocam-pus from the normal rats, the lesionedcytochrome C-treated rats (controls),and the lesioned and NGF-treated ratsat different times after the lesion. NGF-injection for 15 days after the lesionresulted in an increase of the CHATactivity in both the contralateral hippo-campus and the entire septum, to about130% of that in the normal animals,but resulted in a slight increase in theipsilateral lesioned hippocampus whencompared with the activity in the ipsi-lateral side of the cytochrome C-treatedcontrols. NGF-injection for 30 days afterthe lesion resulted in a 48% increase ofthe CHAT activity in the ipsilateralhippocampus as compared with the cyto-chrome C-treated controls, but failed toinduce a significant increase in the con-tralateral hippocampus. These findingsindicate that atrophic cholinergic neuronsin aged animals are similarly responsiveto NGF treatment, like those in theyoung animals. The action mechanism ofNGF was discussed.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
1991年第3期132-135,共4页
Chinese Journal of Nervous and Mental Diseases