摘要
目的观察酒石酸托特罗定联合经皮胫神经电刺激对女性膀胱过度活动症的临床疗效。方法选取2013年4月到2015年7月我院收治的女性膀胱过度活动症患者142例,使用数字法随机分为酒石酸托特罗定对照组和酒石酸托特罗定联合经皮胫神经电刺激观察组,每组71例。记录治疗前后的膀胱过度活动症症状评分表(OABSS)评分、平均24h排尿次数、平均24h尿急次数、平均夜尿次数、平均24h尿失禁次数。比较两组临床疗效不良反应发生率。结果治疗后观察组与对照组OABSS评分分别为(5.7±1.1)分和(7.2±1.3)分、平均24h排尿次数分别为(8.1±1.2)次和(9.2±1.8)次、平均24h尿急次数分别为(1.2±0.4)次和(1.9±0.5)次、平均夜尿次数分别为(1.1±0.3)次和(1.6±0.4)次、平均24h尿失禁次数分别为(1.8±0.5)次和(2.4±0.6)次,差异均具有显著性统计学意义(P<0.05)。观察组临床治疗有效率为87.3%(62/71),显著高于对照组的71.8%(51/71)(P<0.05)。临床不良反应发生率观察组为8.5%(6/71),对照组为7.0%(5/71),两组间差异无统计学意义(P>0.05)。结论托特罗定联合经皮胫神经电刺激对女性膀胱过度活动症临床疗效显著,使用安全,值得推广应用。
Objective To explore the efficacy of Tolterodine combined with percutaneous tibial nerve stimulation（PTNS）on female overactive bladder（OAB）.Methods A total of 142 women with OAB enrolled were divided into Tolterodine group（n=71,control）and Tolterodine combined with PTNS group（n=71,observation group）.The OABSS,average 24 h urination frequency,average 24 h urgent urination frequency,average number of nocturia,and average 24 h urinary incontinence episodes were recorded.The clinical effective rate and adverse reaction rate were compared.Results The OABSS,average 24 h urination frequency,average 24 h urgent urination frequency,average number of nocturia,average 24 h urinary incontinence episodes in the observation group were 5.7±1.1,8.1±1.2,1.2±0.4,1.1±0.3,and1.8±0.5,which were significantly lower than those in the control group（7.2±1.3,9.2±1.8,1.9±0.5,1.6±0.4,and 2.4±0.6）（P〈0.05）.The clinical effective rate was 87.3%（62/71）in the observation group,and71.8%（51/71）in the control group（P〈0.05）.The adverse reaction rate was 8.5%（6/71）in the observation group and 7.0%（5/71）in the control group（P〉0.05）.Conclusion Tolterodine combined with PTNS is safe and effective for female OAB.
出处
《现代泌尿外科杂志》
CAS
2016年第5期357-359,共3页
Journal of Modern Urology
