摘要
目的对比肾部分切除术与肾癌根治术治疗T1b期肾癌的疗效。方法计算机检索PubMed、EMBASE、Cochrane Library和ISI Web of Knowledge,查找2015年8月前所有对比肾部分切除术与肾癌根治术治疗T1b期肾癌的临床试验,同时筛检纳入文献的参考文献,提取数据后采用Stata软件对数据结果进行Meta分析。结果共纳入10篇回顾性对照试验,18 183例患者。5年及10年总体生存率的风险比不具有统计学差异(P>0.05),两种手术方式总体生存率无明显统计学差异;5年及10年肿瘤特异性生存率的风险比具有统计学差异(P<0.05),肾部分切除术具有更高的肿瘤特异生存率和局部复发风险。结论 T1b期肾癌行肾部分切除术虽具有较高的局部复发风险,但总体特异性生存率与肾癌根治术无明显统计学差异,在技术条件允许的条件下肾部分切除术可成为T1b的首选术式。
Objective To compare the oncologic outcomes and efficacy of partial nephrectomy（PN）and radical nephrectomy（RN）for T1b renal carcinoma.Methods Databases including PubMed,EMBASE,Cochrane Library and ISI Web of Knowledge were systematically searched for clinical studies comparing PN and RN for T1b renal carcinoma published before August,2015.Data collected were analyzed with stata software.Results According to predefined inclusion criteria,10 studies involving 18 183 patients were enrolled.There was no significant difference between the PN group and RN group regarding the 5-year and10-year overall survival（OS）（P〈0.05）.However,the PN group had higher 5-year and10-year cancer specific survival（CSS）（P〈0.05）.PN group had higher local recurrence rate and lower distant metastasis rate.Conclusion Our analysis indicates that PN has the same overall specific survival as RN for T1b renal carcinoma despite of higher local recurrence rate.PN may become the preferred operation method for T1b renal carcinoma in some cases.
出处
《现代泌尿外科杂志》
CAS
2016年第5期367-371,共5页
Journal of Modern Urology
