摘要
目的探讨西格列汀联合大剂量胰岛素对2型糖尿病患者血糖及血脂的影响。方法将94例2型糖尿病患者随机分成观察组和对照组,每组47例。对照组患者采用大剂量胰岛素进行治疗,观察组在此基础上给予西格列汀进行治疗。对比两组患者的血糖、血脂水平及低血糖事件、不良反应发生率。结果治疗后,观察组患者的空腹血糖、餐后2小时血糖、糖化血红蛋白、甘油三酯、总胆固醇、低密度脂蛋白水平及低血糖事件发生率均显著低于对照组(P<0.05);观察组患者的高密度脂蛋白水平明显高于对照组(P<0.05);两组患者的不良反应发生率差异无统计学意义(P>0.05)。结论西格列汀联合大剂量胰岛素能够有效改善2型糖尿病患者的血糖和血脂水平,预防低血糖事件,是安全而理想的治疗方式。
Objective To investigate the effects of sitagliptin combined with high dose of insulin on the blood glucose and blood fat levels of patients with type 2 diabetes. Methods 94 patients with type 2 diabetes were randomly divided into the observation group and control group, with 47 cases in each. The control group patients were treated with high dose of in-sulin, the observation group were treated with sitagliptin and high dose of insulin. The blood glucose level, the blood fat lev-el, the hypoglycemia event rate and the incidence of adverse reactions were compared between the two groups. Results After the treatment, the fasting blood glucose level, the 2-hour postprandial blood glucose level, the glycosylated hemoglobin lev-el, the triglyceride level, the total cholesterol level, the low-density lipoprotein level and the hypoglycemia event rate in the observation group were notably lower than those in the control group （P〈0.05）. The high-density lipoprotein level in the ob-servation group was clearly higher than that in the control group （P〈0.05）. There was no significant difference in the inci-dence of adverse reactions between the two groups （P〉0.05）. Conclusion The sitagliptin combined with high dose of insulin can efficaciously improve the blood glucose level and the blood fat level, prevent the hypoglycemia event. It is a safe and ideal treatment.
出处
《糖尿病新世界》
2016年第6期3-5,共3页
Diabetes New World Magazine
关键词
西格列汀
胰岛素
2型糖尿病
血糖
血脂
Sitagliptin
Insulin
Type 2 diabetes
Blood glucose
Blood fat
