摘要
目的:研究通腑泄浊中药对慢性肾衰肠源性毒素以及肠道屏障功能的影响。方法:将60例慢性肾衰患者随机分为灌肠治疗组和对照组,各30例。对照组施予常规基础治疗;灌肠治疗组在对照组治疗基础上加用通腑泄浊中药灌肠治疗。比较治疗后2组患者肠源性毒素和肠道屏障功能。治疗14天。结果:治疗后灌肠治疗组治疗前后硫酸吲哚酚、血肌酐、尿素氮、内毒素、D-乳酸比较,差异有统计学意义(P<0.05),尿酸、肾小球滤过率比较,差异无统计学意义(P>0.05)。治疗后2组硫酸吲哚酚、血肌酐、尿素氮、内毒素、D-乳酸比较,差异有统计学意义(P<0.05)。治疗后灌肠治疗组纳差呕恶、腰膝酸软改善例数与对照组比较,差异有统计学意义(P<0.05)。结论:慢性肾衰患者应用通腑泄浊中药灌肠治疗,有利于机体肠源性毒素的减少和肠道屏障功能的恢复,可明显改善患者临床症状。
Objective：To explore of effect of Tongfu Xiezhuo tang on enterogenous toxin and intestinal barrier function of chronic renal failure. Methods：Sixty cases of patients with chronic renal failure were divided into clysis treatment group and control group randomly,30 cases in each group. The patients in the control group were given conventional therapy. The clysis treatment group was treated with Tongfu Xiezhuo tang on the basis of treatment in the control group. Enterogenous toxin and intestinal barrier function of patients in both groups were observed before and after treatment. The treatment course was 14 days.Results：Compared the Indoxyl sulfate,serum creatinine,urea nitrogen,endotoxin,D- lactate acid in clysis treatment group before and after treatment,the difference was statistical significant（P〈0.05）. Compared uric acid and glomerular filtration rate,the difference was statistical significant（P〈0.05）. Compared the Indoxyl sulfate,serum creatinine,urea nitrogen,endotoxin,D- lactate acid in both groups after treatment,the difference was statistical significant（P〈0.05）. After treatment,comparing the improve case number of poor appetite,nausea,soreness and weakness of waist and knees between clysis treatment group and control group,the difference was statistical significant（P〈0.05）. Conclusion：Clyster using Tongfu Xiezhuo tang for chronic renal failure is benefits to reduce body enterogenous toxin and recover intestinal barrier function, and can improve clinical symptoms of patients preferably.
出处
《新中医》
CAS
2016年第5期102-104,共3页
New Chinese Medicine
基金
广东省中医药局课题(2010385)
关键词
慢性肾衰
肠道屏障功能
肠源性毒素
通腑泄浊中药
Chronic renal failure
Intestinal barrier function
Enterogenous toxin
Tongfu Xiezhuo tang
