摘要
目的:观察风湿清合剂联合阿达木单抗-肿瘤坏死因子(TNF)抑制剂治疗难治性类风湿性关节炎患者的临床效果。方法:选取60例难治性类风湿性关节炎患者,采用随机对照方法分为对照组和实验组各30例,对照组采用阿达木单抗-TNF抑制剂治疗,实验组在对照组治疗基础上联合风湿清合剂治疗,比较2组的疗效、DAS28、关节压痛数、关节肿胀数、僵硬时间、总胆固醇(TC)、红细胞沉降率(ESR)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、C-反应蛋白(CRP)与生活质量评分。结果:治疗后,实验组DAS28、关节压痛数、关节肿胀数均少于对照组,僵硬时间短于对照组,差异均有统计学意义(P<0.05)。治疗后,2组TC、TG、ESR及CRP均较治疗前降低,HDL-C较治疗前升高,差异均有统计学意义(P<0.05);2组各指标比较,差异均有统计学意义(P<0.05)。实验组生理功能、生理职能、躯体疼痛、情感职能、社会功能、精力、精神健康以及总体健康8个方面的评分均高于对照组,差异均有统计学意义(P<0.05)。结论:风湿清合剂联合阿达木单抗-TNF抑制剂治疗难治性类风湿性关节炎可以取得良好的治疗效果,提高患者的生活质量。
Objective：To observe the clinical effect of Fengshiqing mixture combined with adalimumab-TNF inhibitor on treating patients with refractory rheumatoid arthritis. Methods：Sixty cased of patients with refractory matoid arthritis were divide them into the control group and the experimental group adopting stochastic contrast method,30 cases in each group. The adalimumab-TNF inhibitor was given to patients in the control group,Fengshiqing mixture was added in the experimental group on the basis of the treatment of the control group. Compared the clinical effect,Disease Activity Score 28 joint count（DAS28）,tender joint count,swollen joint count,rigid time,total cholesterol（TC）,erythrocyte sedimentation rate（ESR）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,C- reactive protein（CRP） and reactive protein in both groups. Results：After treatment,DAS28,tender joint count and swollen joint count in the experimental group were all less than those in the control group,rigid time was shorter than that in the control group,differences being statistical significant（P〈0.05）. After treatment,TC,TG and CRP in both groups were all lower than those before treatment,and HDL-C was increased comparing with that before treatment, differences being significant（P〈0.05）. Compared every indexes in the two groups, differences were statistical significant（P〈0.05）. The scores of eight aspects such as physiological function, physiological role, body pain,emotion function,energy,mental health and overall health in the experimental group were higher than those in the control group（P〈0.05）. Conslusion：Fengshiqing mixture combined with adalimumab-TNF inhibitor in treating refractory rheumatoid arthritis can obtain good therapeutic effect,and improve life quality of patients.
出处
《新中医》
CAS
2016年第5期143-145,共3页
New Chinese Medicine
