摘要
目的 探究超声内镜引导下无水乙醇灌洗术(EUS-EL)治疗胰腺浆液性囊性肿瘤的临床疗效及安全性。方法回顾性分析第二军医大学长海医院消化内科2012年5月至2014年11月期间收治的13例胰腺浆液性囊性肿瘤患者的临床资料,其中6例接受超声内镜引导下无水乙醇灌洗术治疗及术后随访,另7例仅接受超声内镜引导下囊液抽吸术,进行为期7~36个月的随访。对两组患者临床症状、病灶大小的变化及复发率进行了比较,统计手术相关并发症的情况。结果 EUS-EL治疗组在治疗前后囊肿最大直径分别为(24.8±14.2)mm及(9.0±4.8)mm(P=0.004)。对照组在治疗前后囊肿最大直径分别为(21.3±11.6)mm及(18.6±14.0)mm(P=0.203)。EUS-EL治疗组和对照组的囊肿最大直径的变化分别为-15.8±3.1mm和-2.7±1.9mm(P=0.003)。EUS-EL治疗组无相关并发症发生,也无复发病例。治疗组囊肿完全消除4例,对照组完全消除1例。治疗组5例患者腹痛症状缓解,腹痛缓解1例(P=0.11)。结论 接受EUS-EL治疗胰腺浆液性囊性肿瘤可有效缓解临床症状、减小病灶大小,并发症少,安全性较高。
Objective To introduce a novel clinical treatment of endoscopic ultrasound-guided ethanol lavage (EUS-EL) sessions for ablation of serous cystic neoplasms(SCN) and evaluate its safety and effectiveness. Methods Retrospective review was performed in 13 patients who had been diagnosed with SCN by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) between May 2012 and November 2014 in Changhai Hospital, China. Six patients who accepted EUS-EL were divided into EUS-EL group and the other seven who merely received EUS-FNA were classified as control group. Final analysis was performed after 7-36 months of follow- up. Results The mean maximum cyst diameter of EUS-EL group before and after treatments were (24.8±5.8)mm and (9.0±4.8)mm (P= 0.004), while the mean maximum cyst diameter of control group before and after treatments were (21.3±11.6)mm and (18.6±14.0) mm (P=0.203), and the variation of mean maximum cyst diameter of EUS-EL group and control group was (-15.8±3.1)mm, (-2.7±1.9) mm (P= 0.003), respectively. The procedure related complications and recurrence rate of EUS-EL group was 0 (0/6). The complete cyst resolution rate of both groups was 66.7% and 14.3% (P=0.086). Abdominal pain was improved in 5 members of EUS-EL group (5/5,100.0%) and only 1of 3 patients in control group got pain improved (33.3%). Conclusion Our preliminary experience with EUS-EL shows a potential role for ablation in treating SCN in China, as a safe and efficient approach to treat selected patients, with high rates of complete resolution and pain release, and low rates of complication and recurrence.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2016年第6期479-481,共3页
Chinese Journal of Practical Internal Medicine
基金
国家自然科学基金(81300353)