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HIV-1亚型多样性及其对艾滋病防治影响的研究进展 被引量:9

HIV-1 subtype diversity and its challenges for AIDS prevention and treatment
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摘要 人类免疫缺陷病毒1型(HIV-1)具有高度变异的特性。HIV-1有9种亚型和78种流行重组型,HIV-1亚型在全球呈不均匀分布。HIV-1亚型多样性可对病毒的传播途径和传播能力、毒力和疾病进展、药物敏感性和耐药性、疫苗研发产生影响,使艾滋病的防治形势面临着严峻的挑战。该文对其研究近况作一综述。 Variability is a hallmark of the human immunodeficiency virus type 1( HIV-1),which can be divided into 9 subtypes and 78 circulating recombinant forms( CRFs). HIV-1 subtypes are not evenly distributed around the world,and the diversity of HIV-1 subtypes may exert an influence on transmission routes,infectivity,virulence,disease progression,drug susceptibility,drug resistance and vaccine development and brings great challenges for AIDS prevention and treatment. The research progress of various HIV-1 subtypes is reviewed in this paper.
作者 苏齐鉴 谭毅
出处 《中国临床新医学》 2016年第6期537-540,共4页 CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金 国家自然科学基金项目(编号:81360258) 广西自然科学基金项目(编号:2014GXNSFAA118175)
关键词 人类免疫缺陷病毒 亚型 艾滋病 Human immunodeficiency virus(HIV) Subtype Acquired immunodeficiency disease syn drome(AIDS)
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