摘要
目的探讨高龄老年人（≥80岁）较普通老年人（60~70岁）外周血T淋巴细胞亚群数量及T细胞CD28表达的差异,并观察胸腺肽α1对高龄老人的作用。方法选取高龄老年人及普通老年人各40例,分别检测2组的外周血T淋巴细胞亚群的百分比及T细胞CD28水平。给予高龄老人组胸腺肽α1注射剂1.6 mg,皮下注射,2次/周,疗程为4周,于治疗后4周检测外周血上述免疫指标。结果高龄老年人组较普通老年组外周血CD8＋的百分比及CD4＋CD28＋的表达无差异,而CD4＋的百分比及CD8＋CD28＋的表达明显降低（P〈0.05）。高龄老人应用胸腺肽α1后CD4＋的百分比及CD8＋CD28＋水平明显提高（P〈0.05）。结论高龄老年人较普通老年人免疫功能出现了进一步下降,而胸腺肽α1能明显增强高龄老年人的部分免疫功能。
Objective To investigate the difference of T lymphocyte subsets and CD28 expression in T cells in peripheral blood between the very elderly（ ≥80 years old,n = 40） and the younger elderly（ 60-70 years old,n = 40）,and to investigate the effect of thymosin α1 in the very elderly. Methods The T lymphocyte subsets and CD28 levels in both groups in peripheral blood were detected,and the very elderly group was injected with thymosin α1 1. 6 mg,twice a week,for 4 weeks. Then the above immune parameters of peripheral blood were detected again. Results There were no differences in the percent of CD8＋and CD4＋CD28＋expression between the very elderly and the younger elderly. The percent of CD4＋and CD8＋CD28＋expression was significantly lower（ P〈0. 05） in the very elderly group than those in the younger elderly. After injected with thymosin α1,the percent of CD4＋and CD8＋CD28＋expression were significantly increased in the very elderly（ P〈0. 05）. Conclusions The immune function of the elderly is decreased more significantly than that of the younger elderly,and thymosin α1 can significantly enhance some immune function in very elderly.
出处
《实用老年医学》
CAS
2016年第5期421-423,共3页
Practical Geriatrics
基金
南京军区医学卫生科研基金(11MA101)
