摘要
结合国内外文献综述了缬草属植物化学成分的研究进展,并对该属药用植物的药理活性进行了总结。缬草属植物除含有一定的挥发油外,化学成分主要集中于单萜类、倍半萜类、木脂素类、黄酮类、生物碱类等。其中单萜类成分主要以环烯醚萜类化合物为主,根据其结构是否裂环分为环戊烷环环烯醚萜和裂环环烯醚萜。药理研究表明该属植物具镇静、解痉、抗抑郁、抗肿瘤、抗A1阿糖腺苷受体性和细胞毒性,并对心血管有一定作用。鉴于目前缺少对缬草属研究的系统回顾和综述,该文对近年来发表的缬草属研究文献进行整理和分析,为其进一步开发利用提供依据。
The recent progresses on chemical components and pharmacological activities of the genus Valerianawere summarized. Besides-essential oil,the chemical composition of Valerianais mainly focused on monoterpenoids,sesquiterpenoids,lignans,flavonoids,alkaloids,etc. Iridoids are the main chemical components ofmonoterpenoids. There are two types ofiridoidson the basis of the cyclopentane open or not. The Valerianahas been drawmuch attention for their significant sedation,spasmolysis,antidepression,antitumor,against adenosine A1 receptors and cytotoxicityactivity,and had certain function for cardiovascular disease treatment. Given to the fact of the lack of systematic review and summary of studies on the Valeriana,we summarized and analyze the study literatures on the pharmacological activity of Valerianain recent years,and providedsome basisfor further study.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2016年第8期1405-1414,共10页
China Journal of Chinese Materia Medica
基金
国家基础科学培养基金项目(J13100340-11)
四川省教育厅重点项目(15ZA0093)
成都中医药大学科技发展基金项目(ZRQN1440)
中药药效物质基础研究与创新中药发现四川省青年科技创新研究团队项目(2016TD0006)
四川省中医药管理局基金项目(2016Q049)
关键词
缬草属
化学成分
药理活性
Valeriana
chemical components
pharmacological activities
