摘要
目的观察分析盐酸氨基葡萄糖片治疗类风湿关节炎致膝软骨损伤的临床疗效。方法选取2011年1月-2015年1月期间收治的类风湿关节炎致膝软骨损伤患者200例作为研究对象,按入院时间的不同,分为对照组(n=98)和研究组(n=102),对照组给予常规缓解病情抗风湿药物(DMARD)治疗,研究组在此基础上加用盐酸氨基葡萄糖片治疗,分别于治疗18、36、54周后,对两组患者的治疗效果进行评定。结果治疗54周后,研究组膝关节疼痛评分显示治疗效果明显优于对照组,差异有统计学意义(P<0.05);研究组治疗后的Noyes评价水平低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为3.92%,对照组不良反应发生率为3.06%,两组差异无统计学意义(P>0.05)。结论盐酸氨基葡萄糖片联合DMARD治疗类风湿关节炎致膝软骨损伤临床有效,可促进软骨修复,值得临床使用。
Objective To investigate the clinical efficacy of glucosamine hydrochloride tablets in treating knee cartilage injury resulting from rheumatoid arthritis. Methods We selected 200 knee cartilage injury patients with rheumatoid arthritis treated in our hospital from January 2011 to January 2015 as the research subjects. They were divided into control group （n=98） and observation group （n--102） according to the time of admission. The control group was treated with conventional disease modifying anti-rheumatic drugs （DMARDs）, while the observation group was treated with glucosamine hydrochloride tablets on the basis of DMARDs. The treatment effect was evaluated and compared between the two groups of patients 18, 36 and 54 weeks after the treatment. Results FiRy-four weeks later, knee pain score of the observation group was better than that of the control group, and the difference was statistically significant （P 〈 0.05）. The observation group had a lower Noyes evaluation level than the control group, and the difference was statistically significant （P 〈 0.05）. Adverse reaction in the observation group was 3.92% and it was 3.06% in the control group, and the difference between the two groups was not statisticaUy significant （P 〉 0.05）. Conclusion Glucosamine hydrochloride tablets combined with conventional anti-rheumatic treatment is effective for knee cartilage injury caused by rheumatoid arthritis, which can promote cartilage repair, and it is worthy of clinical application.
出处
《华西医学》
CAS
2016年第5期831-834,共4页
West China Medical Journal
关键词
类风湿关节炎
膝软骨损伤
盐酸氨基葡萄糖
Rheumatoid arthritis
Knee cartilage injury
Glucosamine hydrochloride
