摘要
目的观察盐酸氨基葡萄糖联合抗骨质疏松药治疗老年膝骨关节炎的临床疗效。方法将2014年1月-2015年12月就诊的60岁以上膝骨关节炎患者120例随机分为观察组和对照组(每组60例)。观察组在口服盐酸氨基葡萄糖基础上给予口服碳酸钙D3、阿法骨化醇、阿仑膦酸钠抗骨质疏松治疗,对照组只给予口服盐酸氨基葡萄糖治疗,于用药后第2、4、6周对比两组Lequesne评分、治疗效果和药物不良反应。结果治疗后第2周两组有效率差异无统计学意义(P>0.05)。治疗后第4、6周,观察组有效率高于对照组,差异有统计学意义(χ2=6.806,P<0.01;χ2=24.762,P<0.01);治疗后第4、6周,观察组Lequesne评分低于对照组,差异有统计学意义(t=2.199,P<0.05;t=4.748,P<0.001),两组用药后不良反应比较差异无统计学意义(χ2=0.617,P>0.05)。结论盐酸氨基葡萄糖联合抗骨质疏松药治疗老年膝骨关节炎具有良好的治疗效果,较单一给予盐酸氨基葡萄糖治疗效果更好,且不增加药物不良反应,值得临床推广应用。
Objective To observe the clinical effect of combined glucosamine hydrochloride and anti-osteoporosis drugs in the treatment of senile knee osteoarthritis. Methods A total of 120 patients with osteoarthritis of the knee treated from January 2014 to December 2015 were randomly divided into observation group and control group with 60 cases in each. The observation group received not only oral glucosamine hydrochloride, but calcium D3, alfacalcidol, and sodium phosphate for anti-osteoporosis treatment, while the control group was only given oral glucosamine hydrochloride. Lequesne score, curative effect and adverse drug reactions were compared between the two groups 2, 4, and 6 weeks after the beginning of treatment. Results Within two weeks of treatment, there was no significant difference between the two groups in the effective rate （P 〉 0.05）. But four and six weeks after treatment, the efficiency in the observation group was significantly higher than that in the control group （χ2=6.806, P 〈 0.01;χ2=24.762, P 〈 0.01）. Four and six weeks after treatment, Lequesne score of the observation group was significantly lower than that of the control group （t=2.199, P 〈 0.05; t=4.748, P 〈 0.001）. There was no significant difference in terms of adverse reactions between the two groups before and after treatment （χ2=0.617, P 〉 0.05）. Conclusion Compared with single hydrochloric amino glucose treatment, glucosamine hydrochloride combined with anti-osteoporosis treatment for senile knee osteoarthritis has better treatment effect without increase in adverse drug reactions, and it is worth of clinical application.
出处
《华西医学》
CAS
2016年第5期838-840,共3页
West China Medical Journal
