摘要
目的分析前列腺癌骨转移的形态及脱氧葡萄糖(FDG)代谢特点,探讨PET/CT的临床应用价值。方法回顾性分析27例依据影像、临床或组织病理诊断为前列腺癌骨转移患者的PET/CT资料,总结骨转移瘤的分布、数目、大小、密度及FDG摄取等特点,分析病变大小与最大标准化摄取值(SUVmax)的相关性。结果 27例中,弥漫性转移11例,其中10例PET与CT检出病灶数目大致相符,1例PET发现病灶明显多于CT;多发及单发转移16例,选择测量病变51个,大小平均(1.9±1.0)cm,SUVmax平均为6.5±3.7,二者呈正相关。48个病变代谢活跃,其中成骨性46个(3个病灶PET浓聚范围大于CT所示),溶骨性1个,1个病灶CT未显示;3个病灶代谢与周围骨质接近,其中1个为成骨性改变,另2个CT未显示。结论 PET/CT诊断前列腺癌骨转移的敏感性较高,可能会漏诊代谢不活跃的小病灶。
Objective To investigate the morphological metabolic features of bone metastases on ^（18）F-FDG PET/CT and its clinical value for prostate carcinoma. Methods Twenty-seven patients with prostate carcinoma bone metastases were retrospectively enrolled in the study. Bone metastases were diagnosed according to imaging,clinical data and pathological studies. The imaging features including distribution,number,size,density and SUVmax of bone metastases and the relationship between SUVmax and size were evaluated. Results Eleven patients had diffuse metastases,10 of which showed similar lesions in number on PET and CT. One patient demonstrated more lesions on PET than CT. Fifty-one lesions were selected and measured from 16 patients with multiple or single bone metastases. The SUVmax（ mean 6. 5 ± 3. 7） had a positive correlation with size（ mean 1. 9 ± 1. 0 cm）. Forty-eight lesions were hyper-metabolic,46 were sclerotic on CT,3 of which were larger in size on PET than CT. One lesion was osteolytic and two were negative on CT. Conclusion PET /CT is sensitive in detecting prostate cancer bone metastases except for occasional small hypo-metabolic lesions.
出处
《临床放射学杂志》
CSCD
北大核心
2016年第5期768-771,共4页
Journal of Clinical Radiology
