摘要
探讨成纤维生长因子受体1(FGFR1)、血管内皮生长因子(VEGF)在肺鳞癌中的表达及临床意义。采用免疫组化法检测88例术后肺鳞癌患者癌组织及29例癌旁组织中FGFR1及VEGF的表达。FGFR1、VEGF在肺鳞癌癌组织中的表达率均高于癌旁组织。且二者呈正相关关系。FGFR1的表达吸烟患者高于不吸烟者,VEGF的表达与淋巴结转移、病理分期、分化程度相关。FGFR1的表达与患者总生存期无显著统计学相关。VEGF阳性表达者有明显不良预后。经COX多因素分析FGFR1、VEGF、淋巴结转移、分化程度是肺鳞癌患者术后的独立预后因子。FGFR1和VEGF是肺鳞癌的预后因子,可能成为肺鳞癌靶向治疗的靶点。
To investigate the expression of fibroblast growth factor receptorl （FGFR1）, vascular endothelial growth factor （VEGF） in squamous cell lung cancer and their clinic significance. Immunohistochemicat staining was used to detect the expression of FGFR1 and VEGF in 88 SCC patients undergoing surgical resection and 29 adjacent normal tissues. The positive expression rates of FGFR1, VEGF in squamous cell lung cancer tissues were higher than adjacent normal tissues. There was a significant correlation between FGFR1 and VEGF expression. FGFR1 expression was only associated with smoking, VEGF expression was significantly associated with TNM stage, tumor differentiation and lymph-node status. Survival analysis indicated that FGFR1 （＋）/VEGF（＋） patients had the worst prognosis. Furthermore, multivariate analysis suggested that tumor differentiation, lymph-node metastases, FGFR1 expression and VEGF expression were independent prognostic factors for SCC. The data suggest that FGFR1 and VEGF expressions could serve as prognostic factors and target of targeted therapy for SCC.
出处
《医学与哲学（B）》
2016年第4期67-70,共4页
Medicine & Philosophy(B)
关键词
成纤维生长因子受体1
血管内皮生长因子
肺鳞癌
fibroblast growth factor receptor 1 （FGFR1）, vascular endothelial growth factor （VEGF）, squamous cell lungcancer （SCC）
