2型糖尿病患者血清Spexin水平与血糖和血脂的相关性分析被引量：6

Correlation between serum Spexin level and blood glucose and lipids in patients with type 2 diabetes

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摘要目的了解2型糖尿病(T2DM)患者血清Spexin水平情况,并进一步分析其与血糖和血脂的相关性。方法将226例研究对象分入T2DM组(121例)和对照组(105名),比较两组患者的年龄、性别构成、BMI、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、糖化血红蛋白(HbA_1c)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)和低密度脂蛋白胆固醇(LDL-C)水平。采用ELISA法测定血清Spexin水平,分析其与前述各因素的相关性。结果两组间患者的年龄、性别构成、BMI、SBP、DBP和HDL水平的差异均无统计学意义(P值均>0.05),T2DM组的FPG、HbA_1c、TG、TC、LDL-C水平均显著高于对照组(P值分别<0.05、0.01),血清Spexin水平显著低于对照组(P<0.01)。直线回归分析结果显示,血清Spexin水平与FPG(r=-0.686)、HbA1c(r=-0.632)、TG(r=-0.236)、LDL-C(r=-0.382)均呈负相关(P值均<0.001),与年龄、性别、BMI、SBP、DBP、TC、HDL不相关(P值均>0.05)。多元线性分析结果显示,血清Spexin水平与FPG(t=-5.463,P<0.001)、HbA_1c(t=-2.329,P<0.05)独立相关。结论 T2DM患者血清Spexin水平明显下降,且与TG、LDL-C呈负相关,与FPG和HbA_1c独立相关,提示Spexin作为一种分泌性多肽可能参与了T2DM糖代谢和脂代谢通路。 Objective To explore the level of serum Spexin in patients with type 2 diabetes （T2DM） and the relationship between serum Spexin and blood glucose and lipids. Methods A total of 226 subjects were divided into T2DM group （n = 121 ） and control group （n = 105）. Age, gender composition, body mass index （BMI）, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, fasting plasma glucose （FPG）, glycosylated hemoglobin （HbA1C）, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL） and low density lipoprotein cholesterol （LDL-C） were determined and compared between groups. Serum Spexin was measured by enzyme-linked immunosorbent assay （ELISA）. Results There were no significant differences in age, gender composition, BMI, SBP, DBP or HDL between the two groups （all P^0.05）. FPG, HbA1C, TG, TC, and LDL-C in T2DM group were significantly higher than those in control group （P〈0.05, 0.01 ）, while serum Spexin level in T2DM group was significantly lower than that in control group （P〈 0. 01 ）. Linear regression analysis showed serum Spexin level were negatively correlated with FPG （r = - 0. 686）, HbA1C（ r = - 0. 632）, TG （ r = - 0. 236） and LDL-C （r = - 0. 382, all P〈0.001 ）, but it had no correlation with age, sex, BMI, SBP, DBP, TC or HDL （all P〉0.05）. Multivariate linear analysis showed that serum Spexin level was independently associated with FPG （t=-5.463, P〈0.001） andHbA1C（t=-2.329, P〈0.05）. Conclusion The serum Spexin level is significantly decreased in T2DM patients. It has a negative correlation with TG and LDL-C, is also independently associated with FPG and HbA1C. Spexin, as a secretory polypeptide, may be involved in the glucose and lipid metabolisms in T2DM.

作者顾丽萍顾鸣宇张颖严率李娜马宇航丁晓颖王育璠彭永德

机构地区上海交通大学附属第一人民医院内分泌代谢科

出处《上海医学》 CAS CSCD 北大核心 2016年第3期142-145,共4页 Shanghai Medical Journal

基金国家自然科学基金项目资助(81370904 81100616)

关键词 2型糖尿病 Spexin 血糖血脂 Type 2 diabetes Spexin Serum glucose Serum lipids

分类号 R587.1 [医药卫生—内分泌]

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